{"id":"W4281651554","doi":"10.1016/j.eururo.2022.05.007","title":"Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study","year":2022,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; NIHR Cambridge Biomedical Research Centre; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Oxford Biomedical Research Centre; Canadian Institutes of Health Research; Hutchison Whampoa Limited; Li Ka Shing Foundation; Syöpäjärjestöt; National Institute for Health and Care Research; Weill Cornell Medical College; Centre Léon Bérard; Tampereen Yliopisto; National Health and Medical Research Council; Cancer Research Institute; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Rosetrees Trust; Prostate Cancer Foundation of Australia; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; Prostate Cancer Foundation; Johns Hopkins University; Movember Foundation; Novo Nordisk Fonden; Academy of Finland; Masonic Charitable Foundation","keywords":"Medicine; Prostate cancer; Prostate; Biochemical recurrence; Germline; Oncology; Cancer; Prostatectomy; Internal medicine; Gynecology; Urology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003455705,0.0005063346,0.0007418213,0.0001475363,0.0002783836,0.00003376132,0.0001909947,0.00005402614,0.00126521],"category_scores_gemma":[0.00006100697,0.0003740506,0.000126852,0.0004941968,0.0002318917,0.00007309926,0.0002341084,0.0005162146,0.00002833051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008271661,"about_ca_system_score_gemma":0.000277571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002372942,"about_ca_topic_score_gemma":0.00022129,"domain_scores_codex":[0.9961999,0.0009615048,0.0005027672,0.001110166,0.0004425611,0.0007830717],"domain_scores_gemma":[0.9985782,0.000107234,0.0003463959,0.0005274205,0.0001252591,0.0003154912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009354247,0.009517714,0.9332202,0.0000495684,0.00165011,0.01230323,0.005186285,0.00005853211,0.0004221379,0.000005493148,0.003774918,0.02445757],"study_design_scores_gemma":[0.01796266,0.02069857,0.9320852,0.0001512601,0.001212834,0.0001587915,0.0003471107,0.00006879089,0.0001968709,0.000007238652,0.02658503,0.0005256531],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815127,0.009680193,0.000001646106,0.003841556,0.0003573127,0.002759195,0.001422849,0.0001643868,0.0002601647],"genre_scores_gemma":[0.9902542,0.001921115,0.00002014146,0.001826345,0.000211803,0.004435787,0.0004598201,0.0001327699,0.0007380294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02393191,"threshold_uncertainty_score":0.9998711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717382392327178,"score_gpt":0.2629722313961336,"score_spread":0.2457984074728619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}