{"id":"W4281651554","doi":"10.1016/j.eururo.2022.05.007","title":"Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study","year":2022,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; NIHR Cambridge Biomedical Research Centre; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Oxford Biomedical Research Centre; Canadian Institutes of Health Research; Hutchison Whampoa Limited; Li Ka Shing Foundation; Syöpäjärjestöt; National Institute for Health and Care Research; Weill Cornell Medical College; Centre Léon Bérard; Tampereen Yliopisto; National Health and Medical Research Council; Cancer Research Institute; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Rosetrees Trust; Prostate Cancer Foundation of Australia; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; Prostate Cancer Foundation; Johns Hopkins University; Movember Foundation; Novo Nordisk Fonden; Academy of Finland; Masonic Charitable Foundation","keywords":"Medicine; Prostate cancer; Prostate; Biochemical recurrence; Germline; Oncology; Cancer; Prostatectomy; Internal medicine; Gynecology; Urology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009621937,0.0004034317,0.0004483955,0.0003499046,0.0005047289,0.0006733525,0.0004250511,0.000360171,0.00177643],"category_scores_gemma":[0.001934909,0.0003229044,0.0008123933,0.0008145796,0.0002898987,0.0003084774,0.0005491402,0.0005937998,0.0001058658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153942,"about_ca_system_score_gemma":0.0003474694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004154324,"about_ca_topic_score_gemma":0.005330031,"domain_scores_codex":[0.9994708,0.0001801531,0.00002790342,0.0002292511,0.00004886412,0.00004314103],"domain_scores_gemma":[0.9991098,0.0001911855,0.0002615378,0.0002309463,0.00005403704,0.00015247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001154604,0.00004186348,0.9906617,0.00004454092,0.0007774631,0.0003404189,0.0001769184,0.0003157718,0.001326637,0.0001015365,0.0002419828,0.004816535],"study_design_scores_gemma":[0.0000714196,0.0002964496,0.9961336,0.00001077952,0.0005901959,0.0008114789,0.0001363315,0.001142032,0.0001676906,0.0001569749,0.0004721,0.00001088736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986278,0.0003347027,0.0003729379,0.00003199327,0.000004143766,0.00001483341,0.0003687092,0.00001113649,0.0002337961],"genre_scores_gemma":[0.9994258,0.0000603019,0.0001434976,0.00001231546,0.000005560411,0.000007189669,0.0002751716,0.000004998076,0.00006519879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004154324,"threshold_uncertainty_score":0.00826031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717382392327178,"score_gpt":0.2629722313961336,"score_spread":0.2457984074728619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}