{"id":"W4281652082","doi":"10.1016/j.chom.2022.05.006","title":"Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism","keywords":"Biology; Autoimmune hepatitis; Dysbiosis; Immunology; Autoimmunity; Aryl hydrocarbon receptor; CD8; Cancer research; Gut flora; Immune system; Hepatitis; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109876,0.0003292789,0.0002182142,0.0002236922,0.0001990859,0.000394393,0.0002064449,0.000613243,0.006324785],"category_scores_gemma":[0.0002906257,0.0001813458,0.0002623096,0.0001140132,0.0003923313,0.0001876242,0.0004448797,0.0009979749,0.0008475876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000353672,"about_ca_system_score_gemma":0.0002799813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006951013,"about_ca_topic_score_gemma":0.001360006,"domain_scores_codex":[0.9998024,0.00003106128,0.00001181898,0.00004767077,0.00003997536,0.00006711625],"domain_scores_gemma":[0.9997935,0.00002978858,0.00004641947,0.00001904757,0.00001427806,0.00009703367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001556563,0.000134455,0.006319545,0.0001709639,0.00005249304,0.002643603,0.00007089031,0.0002169047,0.9804898,0.0007787378,0.001510957,0.006055061],"study_design_scores_gemma":[0.0006114689,0.002891871,0.2012821,0.0002367218,0.0004366372,0.02708556,0.001803426,0.008857095,0.7149203,0.004212474,0.03754228,0.0001201143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932019,0.0009104484,0.001348132,0.0005593608,0.000166878,0.00002536301,0.0005558105,0.0002349742,0.002997104],"genre_scores_gemma":[0.9963692,0.0002287246,0.000295619,0.0001949438,0.00002314272,0.00001714918,0.0002144709,0.00002705762,0.002629565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006324785,"threshold_uncertainty_score":0.02115858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548769853991701,"score_gpt":0.2053531955054795,"score_spread":0.1978044256514878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}