{"id":"W4281652082","doi":"10.1016/j.chom.2022.05.006","title":"Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism","keywords":"Biology; Autoimmune hepatitis; Dysbiosis; Immunology; Autoimmunity; Aryl hydrocarbon receptor; CD8; Cancer research; Gut flora; Immune system; Hepatitis; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002017428,0.0003354788,0.0004672274,0.0002579181,0.00073541,0.00006060311,0.0004005474,0.00008352035,0.004678413],"category_scores_gemma":[0.00001446384,0.0003454148,0.0003709953,0.0005627676,0.0001521328,0.0001378226,0.000745669,0.000507884,0.0004099717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000343832,"about_ca_system_score_gemma":0.0002291859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206996,"about_ca_topic_score_gemma":0.00000431581,"domain_scores_codex":[0.9980313,0.0001380076,0.0004493142,0.0005132687,0.0002561407,0.0006120039],"domain_scores_gemma":[0.9987237,0.00005706234,0.0001882532,0.0007430884,0.00009445997,0.000193413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036306,0.001352735,0.0205688,0.0003804615,0.00003903313,0.0001606284,0.001553545,0.000007254355,0.968419,0.00000946806,0.006671045,0.000734414],"study_design_scores_gemma":[0.005230926,0.001426955,0.225655,0.0001704343,0.000742793,0.0002735223,0.002398016,0.000283783,0.5626208,0.00001137971,0.200045,0.001141436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734488,0.01882631,0.00003882038,0.0001986535,0.0005291332,0.0005687634,0.0002235564,0.0001576417,0.006008335],"genre_scores_gemma":[0.9845417,0.001752628,0.0004525595,0.000638287,0.00006687627,0.00004474205,0.0002453649,0.00007213187,0.01218571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4057982,"threshold_uncertainty_score":0.9998998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007548769853991701,"score_gpt":0.2053531955054795,"score_spread":0.1978044256514878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}