{"id":"W4281654583","doi":"10.1002/gcc.23073","title":"Quantitative assessment of copy number alterations by liquid biopsy for neuroblastoma","year":2022,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Swine Innovation Porc; Japan Agency for Medical Research and Development","keywords":"Liquid biopsy; Digital polymerase chain reaction; Neuroblastoma; Loss of heterozygosity; Biopsy; Cell-free fetal DNA; Biology; DNA; Pathology; Copy-number variation; Cancer research; Molecular biology; Gene; Allele; Polymerase chain reaction; Medicine; Cancer; Genetics; Genome; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004748389,0.000103189,0.0002030455,0.00004195571,0.0001924897,0.00001101424,0.00004634082,0.0000155026,0.0007899681],"category_scores_gemma":[0.000005764752,0.00008939066,0.00006476943,0.0001360734,0.00006254074,0.00004474708,0.00006446303,0.00007319247,0.000001565313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006565231,"about_ca_system_score_gemma":0.0001800655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006424781,"about_ca_topic_score_gemma":0.000009580785,"domain_scores_codex":[0.9991676,0.00003929431,0.0001507514,0.0002258148,0.000226277,0.0001902551],"domain_scores_gemma":[0.9995746,0.00006311483,0.00006365682,0.0001212735,0.00007751121,0.00009983953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002549694,0.001299676,0.02559208,0.0004930558,0.0007430286,0.0000816518,0.0004072002,0.0002112591,0.9344012,0.00217181,0.02199435,0.01005496],"study_design_scores_gemma":[0.02178898,0.04198148,0.03397186,0.0002283124,0.0007627362,0.0007229641,0.001684588,0.007295622,0.6028965,0.0003194305,0.2873956,0.0009519599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954543,0.001457852,0.0001853714,0.00100789,0.0001232178,0.0005411686,0.0009572082,0.0000163293,0.000256637],"genre_scores_gemma":[0.995661,0.0008802589,0.0009488108,0.0002356151,0.00004050269,0.0008856296,0.0001073247,0.00002177591,0.001219139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3315047,"threshold_uncertainty_score":0.8649597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02678722232312842,"score_gpt":0.3746329996211643,"score_spread":0.3478457772980358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}