{"id":"W4281663884","doi":"10.1136/rmdopen-2022-002253","title":"Effect of tofacitinib on pain, fatigue, health-related quality of life and work productivity in patients with active ankylosing spondylitis: results from a phase III, randomised, double-blind, placebo-controlled trial","year":2022,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Medicine; Tofacitinib; BASDAI; Ankylosing spondylitis; Placebo; Quality of life (healthcare); Visual analogue scale; Physical therapy; Spondylitis; Minimal clinically important difference; Internal medicine; Posturography; Randomized controlled trial; Arthritis; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002053098,0.00136566,0.003441507,0.0003768715,0.0004644313,0.001145093,0.0007778647,0.001716015,0.004579456],"category_scores_gemma":[0.001714982,0.0004765474,0.002236701,0.0004577532,0.0007901524,0.0007977012,0.0002347076,0.002307294,0.0006233806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007496279,"about_ca_system_score_gemma":0.0008404027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006752083,"about_ca_topic_score_gemma":0.001643534,"domain_scores_codex":[0.9994562,0.0002532499,0.00006837521,0.00008642958,0.00005868359,0.00007695582],"domain_scores_gemma":[0.9990234,0.0002901846,0.0003067088,0.00005088827,0.00008393674,0.000244847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9501936,0.005838954,0.001591907,0.001797712,0.001910832,0.00007727597,0.00008217296,0.0003487444,0.00364991,0.00006418506,0.001018853,0.03342577],"study_design_scores_gemma":[0.9396181,0.05414234,0.004381626,0.00007605435,0.000644038,0.00007417,0.00002342537,0.0002172125,0.0002867525,0.00005888093,0.0004641347,0.00001315233],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713254,0.02221952,0.0003952636,0.0007189356,0.0004565756,0.001922457,0.001113359,0.0001058842,0.001742644],"genre_scores_gemma":[0.9880871,0.006570967,0.0005922952,0.0007261161,0.0004199972,0.001686072,0.0009772312,0.00001224168,0.0009279177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004579456,"threshold_uncertainty_score":0.01531982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733829300283179,"score_gpt":0.3484902624074392,"score_spread":0.3011519694046074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}