{"id":"W4281663884","doi":"10.1136/rmdopen-2022-002253","title":"Effect of tofacitinib on pain, fatigue, health-related quality of life and work productivity in patients with active ankylosing spondylitis: results from a phase III, randomised, double-blind, placebo-controlled trial","year":2022,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Medicine; Tofacitinib; BASDAI; Ankylosing spondylitis; Placebo; Quality of life (healthcare); Visual analogue scale; Physical therapy; Spondylitis; Minimal clinically important difference; Internal medicine; Posturography; Randomized controlled trial; Arthritis; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004329219,0.000276002,0.002201999,0.0001466231,0.0002001112,0.000018384,0.0001240438,0.00006172237,0.000137433],"category_scores_gemma":[0.001522373,0.0002055813,0.0001259619,0.0004401946,0.0001012542,0.0001217162,0.0001731325,0.0003000013,3.70008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780102,"about_ca_system_score_gemma":0.0002071082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004786017,"about_ca_topic_score_gemma":0.0002031377,"domain_scores_codex":[0.9950674,0.002289942,0.001201385,0.0006039315,0.0005472071,0.000290129],"domain_scores_gemma":[0.9963542,0.001962292,0.001033415,0.0004015223,0.000102104,0.0001464447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9588681,0.003498158,0.01525012,0.00006828541,0.0009063592,0.00001755169,0.001916228,0.00002115255,0.000006204441,0.000005094492,0.00005729342,0.01938543],"study_design_scores_gemma":[0.9651009,0.02267684,0.01098283,0.0004174681,0.0001496179,5.564966e-7,0.0002769946,0.000006622005,0.0001712927,0.000008334398,0.00005660998,0.0001519301],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775226,0.000373089,0.000001436228,0.0003209697,0.0001318819,0.01909157,0.002091391,0.00001486567,0.0004521924],"genre_scores_gemma":[0.9968511,0.00001228619,0.0000368638,0.00005885831,0.00002983945,0.001590222,0.001322251,0.00002257594,0.00007604412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01932845,"threshold_uncertainty_score":0.8383363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733829300283179,"score_gpt":0.3484902624074392,"score_spread":0.3011519694046074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}