{"id":"W4281664321","doi":"10.1093/nar/gkac406","title":"Mutations compensating for the fitness cost of rifampicin resistance in<i>Escherichia coli</i>exert pleiotropic effect on RNA polymerase catalysis","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Population Health Research Institute","keywords":"Biology; Virulence; RNA polymerase; Escherichia coli; Mutant; Rifampicin; Genetics; Polymerase; Bacteria; Stringent response; Mutation; Drug resistance; Transcription (linguistics); Genetic Fitness; Gene; Mutation rate; RNA; Bacterial genetics; Microbiology; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009177668,0.0003172431,0.0001926328,0.0001151179,0.00008771712,0.0002233288,0.0001274241,0.0001860893,0.0006696146],"category_scores_gemma":[0.0002083289,0.00009203311,0.0001568408,0.0001130037,0.0001814081,0.00007807529,0.0001258634,0.0002877097,0.0002377244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182218,"about_ca_system_score_gemma":0.0001583284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003329678,"about_ca_topic_score_gemma":0.0005270384,"domain_scores_codex":[0.9998766,0.00002986189,0.00001463173,0.0000237426,0.00003013935,0.00002494671],"domain_scores_gemma":[0.9998744,0.00002907811,0.00004834227,0.00001583434,0.00001058935,0.00002170687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004722008,0.00001244711,0.0003112412,0.00001661896,0.000002728479,0.00004539107,0.000003764266,0.00006467183,0.998746,0.00005101265,0.00001180929,0.0006870148],"study_design_scores_gemma":[0.000006595175,0.0001640254,0.003963533,0.000004069863,0.000009455868,0.0003575028,0.00001529587,0.0007438156,0.9939685,0.00004102665,0.0007214604,0.000004631708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976727,0.0002910819,0.00124752,0.00005404955,0.00001092367,0.00001048471,0.0001013966,0.00005476416,0.0005569599],"genre_scores_gemma":[0.9976361,0.0001970337,0.001530304,0.00002934118,0.00000387554,0.000009611858,0.0001597346,0.00001997208,0.000414017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006696146,"threshold_uncertainty_score":0.002240121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287166037275206,"score_gpt":0.3297612308024043,"score_spread":0.3068895704296523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}