{"id":"W4281664568","doi":"10.1101/2022.06.06.22275997","title":"Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; Jewish General Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; National Institute for Health and Care Research; Jewish General Hospital; Public Health Agency; European Commission; King's College London; Fondation de l'Hôpital général juif; Canadian Institutes of Health Research; Compute Canada; National Institutes of Health; McGill University; Public Health Agency of Canada; Japan Society for the Promotion of Science; Cancer Research UK","keywords":"Mendelian randomization; Mediator; Obesity; Body mass index; Coronavirus disease 2019 (COVID-19); Internal medicine; Bioinformatics; Medicine; Transcriptome; Biology; Endocrinology; Gene; Genetics; Disease; Gene expression; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000892864,0.0002478763,0.0004106142,0.00005748853,0.0001546252,0.00001282096,0.0005086702,0.0002862309,0.0001340635],"category_scores_gemma":[0.0008632032,0.0001878551,0.0002609008,0.0001193186,0.0001077932,0.000003452438,0.0003034374,0.000336543,0.000001144484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007432391,"about_ca_system_score_gemma":0.0003357194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006361139,"about_ca_topic_score_gemma":0.0001074509,"domain_scores_codex":[0.9979942,0.0006867787,0.0003568526,0.0004978324,0.0002924687,0.0001718973],"domain_scores_gemma":[0.9985723,0.0001171646,0.0003740167,0.0007542151,0.00007002627,0.0001122957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003167571,0.0002461973,0.2199584,0.0006620141,0.0001655958,0.000001056985,0.0001464379,0.00479171,0.7703246,0.00001572414,0.0002440383,0.0002766945],"study_design_scores_gemma":[0.002327549,0.0006870602,0.01249806,0.00002138998,0.0000853231,0.000002438529,0.00002239007,0.000167855,0.980202,0.000226897,0.003559922,0.0001990654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966979,0.00009984692,0.000728539,0.0002723794,0.0004832306,0.001361141,0.0001294783,0.00001869626,0.0002087622],"genre_scores_gemma":[0.9987831,0.00009796614,0.00008351545,0.0002076008,0.000113448,0.0002362611,0.0003235507,0.00003082018,0.0001237003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2098775,"threshold_uncertainty_score":0.7660509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212409878616316,"score_gpt":0.270139163599645,"score_spread":0.2580150648134818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}