{"id":"W4281666919","doi":"10.1038/s41591-022-01835-x","title":"Transferability of genetic risk scores in African populations","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"Fogarty International Center; Victor Daitz Foundation; Government of the United Kingdom; Servier; Wellcome; Imperial College London; National Institute for Health and Care Research; St. George's, University of London; South African Medical Research Council; Office of Research and Development; British Heart Foundation; National Human Genome Research Institute; Wellcome Trust; Medical Research Council; London School of Hygiene and Tropical Medicine; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Transferability; Population; Demography; Zulu; Biology; Geography; Medicine; Statistics; Environmental health; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01724388,0.0004586667,0.0004615715,0.002585253,0.0004300706,0.001057024,0.0005061998,0.0004364205,0.001700034],"category_scores_gemma":[0.06037734,0.0001829987,0.0004881132,0.001436141,0.0009252151,0.0008951997,0.00135808,0.0009218016,0.0002750034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265972,"about_ca_system_score_gemma":0.0001679535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0021162,"about_ca_topic_score_gemma":0.00112295,"domain_scores_codex":[0.9897134,0.00761864,0.0004250511,0.001024504,0.0009343187,0.0002839934],"domain_scores_gemma":[0.9638684,0.02335108,0.004361671,0.006024636,0.001899588,0.0004946311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006682839,0.00008153991,0.9489019,0.00003689849,0.001036124,0.0003786393,0.001411575,0.005963269,0.004801269,0.001501323,0.0003054656,0.03491379],"study_design_scores_gemma":[0.00003472123,0.0003972683,0.9683211,0.00005729828,0.000167282,0.0008130563,0.0006571505,0.02076448,0.002145985,0.0058017,0.0007967915,0.00004310681],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919226,0.0001691446,0.006506796,0.000116079,0.00001244847,0.00002367085,0.000191337,0.00003155067,0.001026435],"genre_scores_gemma":[0.9986821,0.00003291215,0.001045788,0.00001612226,0.000007744062,0.000008083219,0.0001258735,0.000007923581,0.00007342682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01724388,"threshold_uncertainty_score":0.0911954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188999796310585,"score_gpt":0.2895472328218893,"score_spread":0.2776572348587835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}