{"id":"W4281669268","doi":"10.1021/acschembio.2c00126","title":"Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; British Heart Foundation; Heart and Stroke Foundation of Canada","keywords":"Sarcomere; Biophysics; Troponin I; Chemistry; Allosteric regulation; Troponin; Troponin C; Stereochemistry; Biochemistry; Biology; Medicine; Cardiology; Receptor; Myocyte; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836002,0.00006918568,0.0002462555,0.00001988985,0.00008194516,8.110775e-7,0.0001308369,0.0000386424,0.00003774522],"category_scores_gemma":[0.00007378926,0.00003813448,0.0001242278,0.0001512516,0.0002734379,0.000007388551,0.0003201177,0.0002005947,0.000001717761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003171456,"about_ca_system_score_gemma":0.00002509785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001473735,"about_ca_topic_score_gemma":1.58108e-7,"domain_scores_codex":[0.9993762,0.00006676512,0.0001963649,0.0001264674,0.00009973681,0.0001344203],"domain_scores_gemma":[0.9995086,0.0001095477,0.0001036837,0.0002160166,0.00004727128,0.0000149404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001579182,0.00005908629,0.007474195,0.00003078513,0.00005258287,0.000002712917,0.0003268484,1.419763e-7,0.9878163,0.0005922061,0.001656936,0.001830301],"study_design_scores_gemma":[0.0009370415,0.0001770194,0.004654633,0.00003760847,0.0001387696,0.0003306729,0.0002708244,0.00001518297,0.9821604,0.0007202776,0.01048085,0.0000767012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994839,0.0008240722,0.000003497468,0.003190007,0.0001501718,0.0001665985,0.00005679586,0.0000101861,0.0007596772],"genre_scores_gemma":[0.9989349,0.00004989203,0.00001854132,0.0007174296,0.0001350859,0.00004441557,0.000025532,0.000004927329,0.00006933414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008823911,"threshold_uncertainty_score":0.1555079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119059052415617,"score_gpt":0.2623974435581717,"score_spread":0.25049153831661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}