{"id":"W4281669268","doi":"10.1021/acschembio.2c00126","title":"Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; British Heart Foundation; Heart and Stroke Foundation of Canada","keywords":"Sarcomere; Biophysics; Troponin I; Chemistry; Allosteric regulation; Troponin; Troponin C; Stereochemistry; Biochemistry; Biology; Medicine; Cardiology; Receptor; Myocyte; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042247,0.000347664,0.0003087752,0.0001146623,0.0001286283,0.0002235623,0.000404821,0.0003144722,0.001999071],"category_scores_gemma":[0.000113849,0.0001449329,0.000223479,0.00008161188,0.0002081139,0.0003690439,0.0001764124,0.0006336576,0.0006087161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368499,"about_ca_system_score_gemma":0.0002068421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004181903,"about_ca_topic_score_gemma":0.000892326,"domain_scores_codex":[0.999922,0.000008516552,0.000007182272,0.00001814001,0.00001948107,0.00002470737],"domain_scores_gemma":[0.9999479,0.000009641945,0.000012576,0.00000461281,0.000008855418,0.00001636509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003100468,0.00009307331,0.0001149017,0.000116544,0.00002596359,0.00006640994,0.00001238242,0.0002817005,0.9944248,0.0004040011,0.0002340405,0.00391612],"study_design_scores_gemma":[0.0001163723,0.00104289,0.000669416,0.00001811341,0.00004105215,0.0001702407,0.00002591681,0.002030949,0.9883427,0.0001125481,0.007415683,0.00001415651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825265,0.004155871,0.006001643,0.0003295582,0.0001384609,0.0001167253,0.0003350015,0.0001866514,0.006209613],"genre_scores_gemma":[0.9836881,0.003333909,0.005503482,0.0003387187,0.00002627327,0.0000985472,0.0005157291,0.0000558592,0.006439339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999071,"threshold_uncertainty_score":0.006687582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119059052415617,"score_gpt":0.2623974435581717,"score_spread":0.25049153831661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}