{"id":"W4281669494","doi":"10.1016/j.ijpharm.2022.121875","title":"New long-acting injectable microspheres prepared by IVL-DrugFluidic™ system: 1-month and 3-month in vivo drug delivery of leuprolide","year":2022,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"inVentiv Health Clinical","funders":"National Research Foundation of Korea; Ministry of Science, ICT and Future Planning","keywords":"Beagle; In vivo; Microsphere; Pharmacokinetics; Drug delivery; Particle size; PLGA; Drug; Pharmacology; Chemistry; Microparticle; Controlled release; Biomedical engineering; Medicine; Internal medicine; In vitro; Chemical engineering; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302952,0.0002590614,0.0002773225,0.0001660032,0.0001248993,0.0002005981,0.0001931881,0.0002496794,0.0005623204],"category_scores_gemma":[0.0001390028,0.0001206393,0.0001949049,0.00009745596,0.0002026,0.0003228665,0.000109051,0.0003022706,0.0001279564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167308,"about_ca_system_score_gemma":0.0001992909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006590751,"about_ca_topic_score_gemma":0.000927716,"domain_scores_codex":[0.9998868,0.00001317538,0.00001109728,0.00003117466,0.00002880832,0.0000289879],"domain_scores_gemma":[0.9998891,0.00001338514,0.00004385417,0.00000635729,0.00001509799,0.00003213441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533444,0.00003949911,0.0001370869,0.00004162932,0.000004267784,0.00003810813,0.00001616568,0.0000511593,0.9967442,0.00004080187,0.00002881286,0.002504976],"study_design_scores_gemma":[0.000049927,0.001291134,0.002017765,0.000002503481,0.00002728075,0.0001516233,0.00001338334,0.000720758,0.9944457,0.00001381168,0.001255388,0.00001083665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904137,0.002048275,0.006567845,0.00005560582,0.00005677251,0.00004020468,0.0001648994,0.0001114739,0.0005412319],"genre_scores_gemma":[0.991915,0.0006090748,0.005529447,0.00002424564,0.00002103864,0.00004370033,0.0001619279,0.00002069931,0.001674835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006590751,"threshold_uncertainty_score":0.001881123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04142166273812704,"score_gpt":0.3850780995198184,"score_spread":0.3436564367816914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}