{"id":"W4281671615","doi":"10.1200/jco.2022.40.16_suppl.tps5615","title":"ENGOT-ov60/GOG-3052/RAMP 201: A phase 2 study of VS-6766 (RAF/MEK clamp) alone and in combination with defactinib (FAK inhibitor) in recurrent low-grade serous ovarian cancer (LGSOC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"KRAS; Medicine; MEK inhibitor; Neuroblastoma RAS viral oncogene homolog; Ovarian cancer; Serous fluid; Cancer; Cancer research; Selumetinib; Internal medicine; MAPK/ERK pathway; Kinase; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161248,0.001490431,0.001526037,0.0006845826,0.0002568377,0.001164165,0.001067712,0.001518521,0.006759966],"category_scores_gemma":[0.0005836984,0.0006830127,0.001388701,0.000473766,0.0008206259,0.001115932,0.0004039518,0.003420093,0.001538965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008120973,"about_ca_system_score_gemma":0.001343773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015232,"about_ca_topic_score_gemma":0.005532283,"domain_scores_codex":[0.99978,0.00007627133,0.00001065157,0.00004030313,0.00002491337,0.00006790995],"domain_scores_gemma":[0.9996386,0.000050498,0.00006607427,0.00002441668,0.00002051511,0.000200043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5096161,0.1120906,0.006949528,0.00355828,0.002172347,0.0007531244,0.0006921922,0.005876158,0.1005207,0.001470693,0.0152151,0.2410851],"study_design_scores_gemma":[0.4119234,0.5597646,0.01093337,0.0001601975,0.0007151829,0.0007800366,0.0002222517,0.002213229,0.005896794,0.0004983349,0.006822046,0.000070624],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820182,0.005586247,0.0009151386,0.0008618069,0.0002271342,0.002909063,0.002452387,0.0003426282,0.004687449],"genre_scores_gemma":[0.9726815,0.006009617,0.002314047,0.001784954,0.0001896644,0.002810176,0.00590068,0.00009418726,0.008215041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006759966,"threshold_uncertainty_score":0.02261436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0909682580429039,"score_gpt":0.456641226699635,"score_spread":0.365672968656731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}