{"id":"W4281673889","doi":"10.3390/curroncol29060321","title":"Promising Therapeutic Impact of a Selective Estrogen Receptor Downregulator, Fulvestrant, as Demonstrated In Vitro upon Low-Grade Serous Ovarian Carcinoma Cell Lines","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fulvestrant; Cancer research; Estrogen receptor; PI3K/AKT/mTOR pathway; Medicine; Serous fluid; Carcinogenesis; Immunohistochemistry; Estrogen; Cell growth; Internal medicine; Oncology; Biology; Signal transduction; Cancer; Cell biology; Breast cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789925,0.0003283197,0.0003457214,0.0002124333,0.00009824441,0.0002753773,0.0001370829,0.0001586288,0.0009068422],"category_scores_gemma":[0.0001226163,0.00006360395,0.0002276464,0.000159763,0.00009739762,0.0001226464,0.000125216,0.0003910152,0.0001536176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370367,"about_ca_system_score_gemma":0.000191349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007570407,"about_ca_topic_score_gemma":0.001601174,"domain_scores_codex":[0.999913,0.00002129272,0.00001020579,0.00001356835,0.00002323225,0.00001865531],"domain_scores_gemma":[0.9999235,0.00002623719,0.00001170414,0.00001414447,0.00000933671,0.00001520327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006804246,0.000217533,0.001015195,0.0001433107,0.00002269179,0.0001083653,0.00004283548,0.0002743682,0.9807956,0.00008436395,0.0002724538,0.01634297],"study_design_scores_gemma":[0.0001902544,0.005735225,0.01429737,0.00001455005,0.00009996192,0.0005181289,0.00004304268,0.001119164,0.9710456,0.00005610362,0.00687452,0.000006047927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894882,0.007242927,0.001237798,0.0001377154,0.00007130876,0.00005368703,0.0004583133,0.0000703722,0.001239549],"genre_scores_gemma":[0.9947256,0.002338074,0.001065857,0.00005828692,0.00001877163,0.00003737257,0.0007286321,0.000007945507,0.001019406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009068422,"threshold_uncertainty_score":0.003033757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04979938805192295,"score_gpt":0.3662855435435635,"score_spread":0.3164861554916405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}