{"id":"W4281674079","doi":"10.1200/jco.2022.40.16_suppl.8032","title":"A novel, immunotherapy-based approach for the treatment of relapsed/refractory multiple myeloma (RRMM): Updated phase 1b results for daratumumab in combination with teclistamab (a BCMA x CD3 bispecific antibody).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Daratumumab; Internal medicine; Oncology; Population; Cytokine release syndrome; Lenalidomide; Multiple myeloma; Gastroenterology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005557084,0.0002237191,0.001538428,0.0003973624,0.0001895794,0.00001451105,0.000340673,0.0002491045,0.0001245242],"category_scores_gemma":[0.001047779,0.0001366573,0.0006454139,0.0004879748,0.0003621587,0.00007754287,0.00002565651,0.0008883339,4.405989e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008824071,"about_ca_system_score_gemma":0.002313283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005364503,"about_ca_topic_score_gemma":0.00005803322,"domain_scores_codex":[0.9954324,0.0005960343,0.002585145,0.0003535689,0.000667164,0.0003656395],"domain_scores_gemma":[0.9886339,0.007867718,0.002111099,0.0004889824,0.0007455799,0.0001527054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5737038,0.08936743,0.001750208,0.00006346217,0.001186644,0.000124726,0.0007322015,0.001174856,0.06773417,0.00007720655,0.001977052,0.2621083],"study_design_scores_gemma":[0.3495185,0.1862062,0.00670522,0.00003908582,0.0002489373,0.000124108,0.0008365262,0.02141733,0.00178935,0.00002987045,0.4329385,0.0001462707],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619729,0.001288303,0.0233324,0.006542257,0.0008347289,0.005104734,0.0003720874,0.00002054187,0.0005320747],"genre_scores_gemma":[0.9832642,0.000534056,0.01397262,0.0003709908,0.0003573669,0.0002911349,0.000367613,0.00006132505,0.0007807043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4309615,"threshold_uncertainty_score":0.5572724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1389415827981114,"score_gpt":0.4666109111669784,"score_spread":0.3276693283688671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}