{"id":"W4281674079","doi":"10.1200/jco.2022.40.16_suppl.8032","title":"A novel, immunotherapy-based approach for the treatment of relapsed/refractory multiple myeloma (RRMM): Updated phase 1b results for daratumumab in combination with teclistamab (a BCMA x CD3 bispecific antibody).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Daratumumab; Internal medicine; Oncology; Population; Cytokine release syndrome; Lenalidomide; Multiple myeloma; Gastroenterology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002782277,0.0007623109,0.001267963,0.0005433891,0.0002667285,0.0008977238,0.0009285663,0.0007763599,0.002060513],"category_scores_gemma":[0.0008803554,0.0003058786,0.001209571,0.0005240623,0.0003086772,0.0007885412,0.0004624508,0.00158696,0.0004981526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008595756,"about_ca_system_score_gemma":0.001111111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003106,"about_ca_topic_score_gemma":0.003588653,"domain_scores_codex":[0.9994372,0.0002313673,0.00005202406,0.00006690401,0.0001301085,0.0000823775],"domain_scores_gemma":[0.9994171,0.0001040753,0.0002296243,0.00004045225,0.0000805885,0.0001282486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0590172,0.01194745,0.02013096,0.004378679,0.002816495,0.0005924948,0.0003362105,0.003777202,0.1110861,0.0004535768,0.01452012,0.7709435],"study_design_scores_gemma":[0.1633751,0.3812695,0.2039808,0.001362824,0.01054321,0.007043608,0.0002589965,0.006280149,0.05792434,0.0006459971,0.1671309,0.0001847024],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8576802,0.119149,0.004054026,0.00340696,0.0004377774,0.003631734,0.004973662,0.00037737,0.006289321],"genre_scores_gemma":[0.9129525,0.04883646,0.01478389,0.005089136,0.0004966264,0.002489001,0.01224996,0.0001067565,0.00299564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002782277,"threshold_uncertainty_score":0.01471424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1389415827981114,"score_gpt":0.4666109111669784,"score_spread":0.3276693283688671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}