{"id":"W4281675691","doi":"10.1155/2022/7414628","title":"Successful Treatment of Drug-Resistant Seizures Secondary to Ring 20 Mosaicism with Perampanel as an Add-On Antiepileptic Drug","year":2022,"lang":"en","type":"article","venue":"Case Reports in Pediatrics","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Perampanel; Medicine; Ring chromosome; Epilepsy; Levetiracetam; Lamotrigine; Refractory (planetary science); Pediatrics; Drug; Electroencephalography; Cognitive decline; Drug Resistant Epilepsy; Chromosome; Psychiatry; Karyotype; Genetics; Internal medicine; Biology; Disease; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148384,0.0004897568,0.0004830753,0.0004455602,0.0003805671,0.000193161,0.0002986803,0.0008317838,0.0003953543],"category_scores_gemma":[0.0006036627,0.0001621354,0.0003166862,0.0001858304,0.0003304471,0.0003145102,0.0004278076,0.0008035382,0.0001489197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306516,"about_ca_system_score_gemma":0.0002827457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000420549,"about_ca_topic_score_gemma":0.000806059,"domain_scores_codex":[0.999872,0.00002742401,0.00001785434,0.00002608685,0.00002353399,0.00003312816],"domain_scores_gemma":[0.9998011,0.00005531191,0.00004078382,0.0000199832,0.00000916205,0.00007373898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000205202,0.0001756626,0.009551914,0.0001083745,0.000034286,0.930682,0.0002139902,0.0005744933,0.02520202,0.0006160348,0.0006411029,0.03199498],"study_design_scores_gemma":[0.00005543846,0.0006047561,0.009114083,0.00001732574,0.00002226134,0.9791899,0.00006104724,0.0008767984,0.007118691,0.0003206374,0.002605578,0.00001346119],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829292,0.005124706,0.00606209,0.001720057,0.0001403969,0.00008798055,0.00007575073,0.0002236708,0.00363617],"genre_scores_gemma":[0.9947675,0.001778376,0.002220063,0.000343235,0.00007779892,0.00001971144,0.0000513845,0.00002511762,0.0007166855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008317838,"threshold_uncertainty_score":0.00167352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006900497322822928,"score_gpt":0.2308675597201169,"score_spread":0.2239670623972939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}