{"id":"W4281676882","doi":"10.1200/jco.2022.40.16_suppl.102","title":"Largest evaluation of acquired resistance to sotorasib in <i>KRAS</i> p.G12C-mutated non–small cell lung cancer (NSCLC) and colorectal cancer (CRC): Plasma biomarker analysis of CodeBreaK100.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Amgen","keywords":"KRAS; Medicine; Colorectal cancer; Internal medicine; Oncology; Clinical endpoint; Lung cancer; Progression-free survival; Cancer; Biomarker; Tumor progression; Overall survival; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003346282,0.0006188077,0.001202661,0.0004017119,0.000321065,0.0007831551,0.0005254786,0.0005569814,0.002345983],"category_scores_gemma":[0.003144924,0.0002887606,0.0008004496,0.0004669302,0.0003724028,0.0004493713,0.0006599061,0.0009950924,0.0004073342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009661147,"about_ca_system_score_gemma":0.001011817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009117312,"about_ca_topic_score_gemma":0.00238734,"domain_scores_codex":[0.9989541,0.0004183176,0.00007439988,0.0002415831,0.0002473213,0.00006423544],"domain_scores_gemma":[0.996838,0.0009888668,0.000724315,0.0004457201,0.0003474047,0.0006557431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.325534,0.004526466,0.3664302,0.001888757,0.006357514,0.001058992,0.0005285672,0.004110911,0.1445878,0.0002852021,0.008794999,0.1358966],"study_design_scores_gemma":[0.04273754,0.124138,0.7576239,0.0001335609,0.006869327,0.004013044,0.0002328674,0.002938091,0.03887418,0.0002522249,0.02205818,0.0001292077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894468,0.001850224,0.0005396075,0.0001542073,0.00002192115,0.0004838769,0.005678756,0.00005918496,0.001765421],"genre_scores_gemma":[0.9874176,0.0004750387,0.00079809,0.0001825827,0.0000257347,0.000221002,0.01033054,0.00002315272,0.0005262737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003346282,"threshold_uncertainty_score":0.01769704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07079144942081898,"score_gpt":0.4815799274940094,"score_spread":0.4107884780731904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}