{"id":"W4281678078","doi":"10.1093/neuonc/noac079.448","title":"MEDB-74. Serial assessment of measurable residual disease in medulloblastoma liquid biopsies","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Medicine; Minimal residual disease; Oncology; Biomarker; Liquid biopsy; Internal medicine; Cerebrospinal fluid; Prospective cohort study; Surrogate endpoint; Pathology; Cancer; Biology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009450314,0.000217142,0.00042767,0.0007691365,0.0002344819,0.0005471853,0.0002441343,0.000261202,0.001471236],"category_scores_gemma":[0.001413509,0.0001314159,0.000149438,0.0004105334,0.0002575399,0.0002575783,0.0002719396,0.0002904384,0.000436255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005807755,"about_ca_system_score_gemma":0.0002921183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002843417,"about_ca_topic_score_gemma":0.00345325,"domain_scores_codex":[0.9995139,0.0001363899,0.0000378771,0.0001022264,0.0001540124,0.00005557818],"domain_scores_gemma":[0.9993454,0.0001686647,0.0001994637,0.00003972297,0.0001278991,0.0001188643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007994494,0.0002274151,0.8132823,0.0002659586,0.0001405099,0.001080369,0.0002200236,0.0006443569,0.1196161,0.0002145238,0.001574418,0.05473963],"study_design_scores_gemma":[0.0002195918,0.003383043,0.9005839,0.00006356152,0.0001189079,0.004699845,0.0002327806,0.002635398,0.08032296,0.0002005451,0.007518852,0.00002076948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888712,0.004352055,0.001973025,0.0001323434,0.00002830864,0.000149693,0.002235907,0.000131625,0.002125846],"genre_scores_gemma":[0.9953359,0.0004946099,0.001947318,0.00007608075,0.00000865201,0.00008986502,0.001401304,0.00001650153,0.0006298672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002843417,"threshold_uncertainty_score":0.005653799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321935994762428,"score_gpt":0.2857020498579654,"score_spread":0.2724826899103411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}