{"id":"W4281678220","doi":"10.1038/s41598-022-13267-1","title":"Discovery of Rift Valley fever virus natural pan-inhibitors by targeting its multiple key proteins through computational approaches","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Qassim University","keywords":"Rift Valley fever; Virology; Viral replication; Biology; Drug discovery; Virtual screening; Arbovirus; Computational biology; Antiviral drug; Docking (animal); Virus; Bioinformatics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003145516,0.001065035,0.001539088,0.0008772195,0.0004222536,0.0007785792,0.0007787729,0.0006964609,0.001776129],"category_scores_gemma":[0.0004976896,0.0003645676,0.001281467,0.0006370109,0.0002157033,0.0005497715,0.0005088086,0.0005735338,0.000217763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005109807,"about_ca_system_score_gemma":0.001079256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004000945,"about_ca_topic_score_gemma":0.007163382,"domain_scores_codex":[0.9998914,0.00002809839,0.000006242631,0.00001877493,0.00002716956,0.00002828484],"domain_scores_gemma":[0.9998753,0.00006420473,0.00001841785,0.000005363991,0.00002066939,0.00001603469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004372558,0.000455371,0.004992456,0.0008235237,0.000601271,0.0005797177,0.00004864304,0.941054,0.01226745,0.005729235,0.001973452,0.03103761],"study_design_scores_gemma":[0.0001116089,0.000277427,0.0004672298,0.00002479557,0.0001681302,0.00007018288,0.00004909237,0.9936036,0.00161491,0.00179041,0.001811278,0.00001132652],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8574615,0.01403392,0.09944409,0.001538777,0.0002442813,0.0003668314,0.002099104,0.001560634,0.02325087],"genre_scores_gemma":[0.9349735,0.003675213,0.0566275,0.0004446609,0.00004442142,0.0003433153,0.001699949,0.000085492,0.002105885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004000945,"threshold_uncertainty_score":0.007955313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961852251674629,"score_gpt":0.2573281842504491,"score_spread":0.2277096617337028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}