{"id":"W4281683551","doi":"10.1093/noajnl/vdac090","title":"Sustained and durable response with Alisertib monotherapy in the treatment of relapsed Atypical Teratoid Rhabdoid Tumor (ATRT)","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Atypical teratoid rhabdoid tumor; Medicine; Oncology; Internal medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028526,0.0001230014,0.0001841435,0.00003681769,0.0001303041,0.000006192416,0.0001291916,0.00003892646,0.00001664752],"category_scores_gemma":[0.00003576148,0.00008243718,0.00003794122,0.0001088502,0.0001295009,0.00000479529,0.00003330257,0.000089908,2.102174e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000490719,"about_ca_system_score_gemma":0.0001558458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001062082,"about_ca_topic_score_gemma":0.00007446584,"domain_scores_codex":[0.9988102,0.0004521612,0.000182896,0.0002817206,0.000100504,0.0001724889],"domain_scores_gemma":[0.9994662,0.0001556809,0.00009452414,0.0002308373,0.00002580148,0.00002690128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04430157,0.0006483829,0.006972244,0.00001712251,0.0000380848,0.0001418162,0.001344161,0.004428852,0.931641,0.00004810412,0.0003247873,0.01009387],"study_design_scores_gemma":[0.0128138,0.03563158,0.00634701,0.00001352633,0.00004982941,0.0005917748,0.005857132,0.0008306998,0.2203483,0.0003771071,0.7167298,0.000409461],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994172,0.004071839,0.00004098775,0.001226764,0.00006537772,0.0002859974,0.00001258344,0.000007398358,0.0001170358],"genre_scores_gemma":[0.9970468,0.001339599,0.0003199328,0.0009517588,0.00003969267,0.0001922395,0.00001230909,0.00001401509,0.00008366549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.716405,"threshold_uncertainty_score":0.3361691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00680939826566008,"score_gpt":0.2654755085352774,"score_spread":0.2586661102696173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}