{"id":"W4281685884","doi":"10.1093/neuonc/noac079.222","title":"HGG-06. Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma without H3 K27M or BRAF Mutations: A Report from the Children's Oncology Group ACNS1721 Study","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"","keywords":"Veliparib; Temozolomide; Medicine; Internal medicine; Oncology; Radiation therapy; PARP inhibitor; Chemotherapy; Glioma; Cancer research; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001979092,0.00153133,0.001986924,0.0004613958,0.0004188981,0.0008730162,0.001095058,0.00122199,0.002719268],"category_scores_gemma":[0.0008108794,0.00075981,0.001509054,0.0005948228,0.0009858622,0.0006851929,0.0004511549,0.002545175,0.0007288094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001378385,"about_ca_system_score_gemma":0.002612315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001893929,"about_ca_topic_score_gemma":0.00468527,"domain_scores_codex":[0.999353,0.000340434,0.00003343998,0.0001128564,0.00005415705,0.0001060937],"domain_scores_gemma":[0.9992568,0.00009135869,0.0001365806,0.00008604441,0.00004284146,0.0003862872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8735358,0.04711893,0.01807147,0.0005841808,0.001809678,0.0002497163,0.0002354725,0.001895662,0.01458919,0.0001617267,0.002538995,0.0392091],"study_design_scores_gemma":[0.6873949,0.2878169,0.0200657,0.0000290877,0.0006155368,0.0002550464,0.00004358152,0.0004090132,0.001668415,0.0001090575,0.00157099,0.00002187466],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926565,0.001247804,0.0002310358,0.000217247,0.00005805683,0.002803945,0.001817828,0.00005498168,0.00091259],"genre_scores_gemma":[0.9836006,0.001577296,0.002217577,0.0008538516,0.0001464655,0.004530704,0.005234275,0.00003538723,0.001803829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002719268,"threshold_uncertainty_score":0.01046658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189601658187891,"score_gpt":0.2865408807553826,"score_spread":0.2746448641735037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}