{"id":"W4281685884","doi":"10.1093/neuonc/noac079.222","title":"HGG-06. Phase 2 Study of Veliparib and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma without H3 K27M or BRAF Mutations: A Report from the Children's Oncology Group ACNS1721 Study","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"","keywords":"Veliparib; Temozolomide; Medicine; Internal medicine; Oncology; Radiation therapy; PARP inhibitor; Chemotherapy; Glioma; Cancer research; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005029361,0.0004099463,0.001189462,0.0002634539,0.0003407402,0.00002757079,0.0002167586,0.0001388163,0.0000551621],"category_scores_gemma":[0.0006394242,0.0002786733,0.00005263178,0.0008317371,0.0003082986,0.0001221439,0.0002664245,0.0005289062,0.000001758866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004795453,"about_ca_system_score_gemma":0.0004090758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00371152,"about_ca_topic_score_gemma":0.004502596,"domain_scores_codex":[0.9958525,0.001045119,0.001032859,0.001028079,0.0005858717,0.0004555238],"domain_scores_gemma":[0.9964601,0.00176385,0.0007596471,0.0006299673,0.000171178,0.0002152648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00497026,0.04007643,0.9310337,0.000007608905,0.0005944518,0.004904654,0.004630836,0.00008943892,0.0009504647,0.000008887793,0.004959764,0.007773513],"study_design_scores_gemma":[0.1039146,0.04396167,0.8409801,0.00001930242,0.0008904826,0.0003783762,0.007395523,0.0001128184,0.00007993067,0.00001806873,0.002022437,0.000226662],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914392,0.0002741937,0.00001947852,0.0019097,0.0002670682,0.00580808,0.0002217942,0.00004658465,0.00001387412],"genre_scores_gemma":[0.9961451,0.00003810575,0.0001796134,0.0008802164,0.00005841447,0.002045355,0.0005881303,0.00005851388,0.000006602774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09894434,"threshold_uncertainty_score":0.9999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189601658187891,"score_gpt":0.2865408807553826,"score_spread":0.2746448641735037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}