{"id":"W4281690762","doi":"10.1038/s41586-022-04797-9","title":"Combination anti-HIV antibodies provide sustained virological suppression","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Medicine; Monoclonal antibody; Placebo; Immunology; Adverse effect; Virology; Antibody; Clinical trial; Internal medicine; Viral load; Combination therapy; Human immunodeficiency virus (HIV); Antiretroviral therapy; Lentivirus; Monoclonal; Viral disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003487135,0.0006140697,0.0009340495,0.0004448299,0.0002557976,0.0008331823,0.0005815166,0.0007163767,0.006821997],"category_scores_gemma":[0.0003134846,0.0003340444,0.0005445863,0.0002965791,0.0002304693,0.0006096466,0.0003261151,0.002138174,0.001407461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268911,"about_ca_system_score_gemma":0.0003062451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003047339,"about_ca_topic_score_gemma":0.0009650371,"domain_scores_codex":[0.9997019,0.00007703687,0.00001370731,0.00003968666,0.00006031512,0.0001073797],"domain_scores_gemma":[0.9997186,0.00007515911,0.00004450173,0.00004601791,0.00002380201,0.00009185592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02414582,0.007070403,0.003774978,0.0004747958,0.0005531599,0.0005827351,0.0001170698,0.00213038,0.5939617,0.002274612,0.01129978,0.3536147],"study_design_scores_gemma":[0.01774624,0.1655194,0.0434239,0.0001685576,0.001575251,0.008749139,0.0002975981,0.01168917,0.6467884,0.00323663,0.1006783,0.0001272803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466506,0.02104376,0.006750946,0.0009379994,0.001383006,0.0003917868,0.0008735648,0.0009093609,0.02105895],"genre_scores_gemma":[0.9877402,0.002826383,0.002254502,0.000294295,0.0003900341,0.0001129449,0.0004766208,0.00006712242,0.00583796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006821997,"threshold_uncertainty_score":0.02282184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007545852132612106,"score_gpt":0.2712382825671129,"score_spread":0.2636924304345007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}