{"id":"W4281691501","doi":"10.1002/ctd2.40","title":"Overview of recent advances in Vero cells genomic characterization and engineering for high‐throughput vaccine manufacturing","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Discovery","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Vero cell; Virology; Bioprocess; Biology; Cell culture; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00208364,0.001101456,0.001242293,0.002394918,0.0002984395,0.002243337,0.0009037146,0.001071933,0.001955566],"category_scores_gemma":[0.001435416,0.0007325558,0.001294168,0.002072896,0.0005180844,0.001591504,0.0007507781,0.001760078,0.001725205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008699492,"about_ca_system_score_gemma":0.0009428873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000773316,"about_ca_topic_score_gemma":0.0007572215,"domain_scores_codex":[0.998887,0.0002474811,0.0001526811,0.0001983326,0.0004402632,0.00007434332],"domain_scores_gemma":[0.9985883,0.0006986299,0.000235866,0.00009046148,0.0003312887,0.00005553984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001896188,0.0002201224,0.0008959058,0.0258725,0.0001969183,0.0005918623,0.0003530411,0.003778862,0.2823731,0.01132714,0.01143054,0.6627704],"study_design_scores_gemma":[0.00002671004,0.0006267069,0.001957634,0.001623599,0.0003090607,0.001641281,0.0001509777,0.003073244,0.1785508,0.004255113,0.8076419,0.0001430192],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008331864,0.9126431,0.0658434,0.001335511,0.0006850883,0.000209343,0.0006495694,0.00044014,0.009861946],"genre_scores_gemma":[0.03069889,0.912694,0.04958115,0.0006946184,0.0005505424,0.0002186697,0.001773847,0.0001325507,0.003655702],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002394918,"threshold_uncertainty_score":0.01101947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235398614249051,"score_gpt":0.3047997320172878,"score_spread":0.2812598705923827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}