{"id":"W4281692879","doi":"10.1172/jci156243","title":"α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; University of Pennsylvania; National Institutes of Health; Vanderbilt University","keywords":"Autoantibody; Glutamate decarboxylase; Islet; Medicine; Cell; Internal medicine; Diabetes mellitus; Endocrinology; Immunology; Biology; Antibody; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423743,0.0001209787,0.0002993773,0.00009958554,0.00007959766,0.00002776999,0.0001970442,0.0001598352,0.00006263834],"category_scores_gemma":[0.0006023063,0.0001216194,0.0002052615,0.0001840642,0.00008180498,0.00001734713,0.0001063533,0.0004785444,0.000005880301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004038718,"about_ca_system_score_gemma":0.0002549885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002733635,"about_ca_topic_score_gemma":0.000008294287,"domain_scores_codex":[0.9977595,0.0005425109,0.0009726607,0.0002220387,0.0003203828,0.0001829502],"domain_scores_gemma":[0.9985794,0.0001304245,0.0009171722,0.000133726,0.0001077528,0.000131516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001996299,0.0006610365,0.5487914,0.00000996937,0.0002038257,0.00002116998,0.0002639587,0.002430928,0.4329417,0.00002958403,0.008640112,0.005806603],"study_design_scores_gemma":[0.008522058,0.003431621,0.705088,0.00009175861,0.0002441671,0.000006958714,0.0008634824,0.001455135,0.2625167,0.006382305,0.01085442,0.0005434186],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973155,0.00078705,0.000130974,0.0006770941,0.0006747592,0.0001067318,0.00005261864,0.000004093497,0.0002511752],"genre_scores_gemma":[0.9971369,0.0001571438,0.0005328833,0.001532988,0.0002931209,0.000005703798,0.0002555123,0.00001658661,0.00006914185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.170425,"threshold_uncertainty_score":0.4959497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562173158430163,"score_gpt":0.2915426766168644,"score_spread":0.2759209450325628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}