{"id":"W4281692879","doi":"10.1172/jci156243","title":"α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; University of Pennsylvania; National Institutes of Health; Vanderbilt University","keywords":"Autoantibody; Glutamate decarboxylase; Islet; Medicine; Cell; Internal medicine; Diabetes mellitus; Endocrinology; Immunology; Biology; Antibody; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607651,0.0003623803,0.000205989,0.0006956062,0.0004880767,0.0005849316,0.0001733293,0.0002743228,0.001849737],"category_scores_gemma":[0.0003438224,0.0001795718,0.0002183432,0.0004140289,0.0002239179,0.0001598636,0.0002884708,0.0003736088,0.0003586361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586034,"about_ca_system_score_gemma":0.00008540219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004055015,"about_ca_topic_score_gemma":0.0004689445,"domain_scores_codex":[0.9998486,0.0000163369,0.0000199608,0.00006729664,0.00002669233,0.00002117251],"domain_scores_gemma":[0.9998266,0.00002030465,0.00005649968,0.00002241731,0.000019525,0.00005461955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004227792,0.0002639276,0.4312832,0.0003525605,0.0002348365,0.004653371,0.0009982444,0.0003262139,0.5216049,0.0002057103,0.001100425,0.03474883],"study_design_scores_gemma":[0.00008792776,0.0009980396,0.9384443,0.00005630382,0.0002353183,0.01502194,0.0005314422,0.0003958772,0.03935761,0.0003467936,0.004497068,0.00002741641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977609,0.0008769578,0.0003910001,0.00003543255,0.00002742403,0.00001406768,0.0004694941,0.00001656951,0.0004081443],"genre_scores_gemma":[0.9975753,0.0005939524,0.0005638755,0.00009093781,0.0000225142,0.00002107895,0.0006951981,0.00001373358,0.0004233761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001849737,"threshold_uncertainty_score":0.006187975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562173158430163,"score_gpt":0.2915426766168644,"score_spread":0.2759209450325628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}