{"id":"W4281694128","doi":"10.1161/circresaha.122.320991","title":"Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease","year":2022,"lang":"en","type":"article","venue":"Circulation Research","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"College of Medicine, University of Florida; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; INCLIVA Instituto de Investigación Sanitaria; Universidad de La Frontera; MedStar Health Research Institute; Jewish General Hospital; National Institutes of Health; Georgetown-Howard Universities Center for Clinical and Translational Science; Karl-Franzens-Universität Graz; McGill University; University of Oklahoma Health Sciences Center; Texas Biomedical Research Institute; University of Oklahoma; University of Washington; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Larner College of Medicine, University of Vermont; Johns Hopkins Bloomberg School of Public Health; University of Southern California","keywords":"Arsenic; DNA methylation; Epigenetics; Methylation; Diabetes mellitus; Prospective cohort study; Framingham Heart Study; Disease; Internal medicine; Cohort; Medicine; Framingham Risk Score; Gene; Biology; Endocrinology; Genetics; Chemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001942625,0.0000672919,0.00008066829,0.0001095857,0.0007686503,0.00004105959,0.0001203455,0.00002236742,0.003911673],"category_scores_gemma":[0.0001690161,0.00007690503,0.00007010821,0.0005242378,0.0001358582,0.000194819,0.000294642,0.0001971796,0.0000873738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276712,"about_ca_system_score_gemma":0.00003401183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001150695,"about_ca_topic_score_gemma":0.00001226361,"domain_scores_codex":[0.9975601,0.0005355704,0.0001570551,0.0003566414,0.0011839,0.0002067391],"domain_scores_gemma":[0.9993527,0.00009300451,0.00002804209,0.0003412825,0.00003554357,0.0001494348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006127994,0.0003869357,0.569035,0.00003969327,0.0002742577,0.00007848963,0.003633256,0.1423165,0.02531093,0.008351154,0.003156749,0.2473557],"study_design_scores_gemma":[0.0006316363,0.00003636242,0.9542164,0.000002344168,0.00004342748,0.00001000566,0.0005003172,0.01514749,0.0001683179,0.003452781,0.02564607,0.0001448465],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921594,0.0005484436,0.0008199659,0.0004609628,0.0000594395,0.0004166516,0.000007151901,0.000039447,0.005488539],"genre_scores_gemma":[0.9986376,0.00002857241,0.00005566532,0.00005524159,0.00002953487,0.0001383638,0.00004010049,0.0000114566,0.001003533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3851814,"threshold_uncertainty_score":0.9969989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04240551056283244,"score_gpt":0.286270211576377,"score_spread":0.2438647010135446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}