{"id":"W4281694566","doi":"10.1007/s13311-022-01251-6","title":"Updates in IDH-Wildtype Glioblastoma","year":2022,"lang":"en","type":"review","venue":"Neurotherapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Glioblastoma; Neurology; Medicine; Neurosurgery; Wild type; Brain tumor; Oncology; Internal medicine; Bioinformatics; Neuroscience; Cancer research; Biology; Pathology; Gene; Surgery; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001059174,0.0004317214,0.001418922,0.0004311132,0.00006116372,0.00002635419,0.00018073,0.0001836376,0.001376504],"category_scores_gemma":[0.00002065991,0.0003428241,0.0004407234,0.0006745019,0.00003506403,0.00002325279,0.00006663583,0.0005991052,0.0002031938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215907,"about_ca_system_score_gemma":0.0002273034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001115418,"about_ca_topic_score_gemma":0.00001495091,"domain_scores_codex":[0.9981661,0.0001557376,0.0005005612,0.0004700803,0.0003215534,0.0003859711],"domain_scores_gemma":[0.998907,0.0002319429,0.000165736,0.0005785157,0.00001548991,0.0001013464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000231132,0.0006081208,0.0001805952,0.002458757,0.000184819,0.0009614639,0.0000280918,5.931811e-7,0.000001019934,0.0001344657,0.0003929294,0.9950261],"study_design_scores_gemma":[0.000734874,0.0006096829,0.00003613197,0.00150995,0.0009428267,0.0003758314,0.000006896747,0.000007170923,0.000007598377,0.00001742538,0.9955279,0.0002237435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007247188,0.9964844,4.990296e-7,0.0001491084,0.0003184961,0.001292798,0.00003544507,0.00007469612,0.001572069],"genre_scores_gemma":[0.00005264694,0.9979028,0.00004803825,0.00102695,0.0001103512,0.0004392886,0.00007702439,0.0001469288,0.0001959578],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9951349,"threshold_uncertainty_score":0.9999024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09257305351057138,"score_gpt":0.3710001645915484,"score_spread":0.2784271110809771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}