{"id":"W4281698533","doi":"10.1016/j.jaip.2022.05.019","title":"Effect of Dupilumab on Blood Eosinophil Counts in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis, or Eosinophilic Esophagitis","year":2022,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"National Institutes of Health; Regeneron Pharmaceuticals; Sanofi","keywords":"Eosinophilia; Eosinophilic esophagitis; Dupilumab; Medicine; Eosinophil; Atopic dermatitis; Asthma; Nasal polyps; Internal medicine; Eosinophilic; Gastroenterology; Immunology; Interleukin 5; Benralizumab; Dermatology; Mepolizumab; Pathology; Disease; Interleukin; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006306277,0.000568327,0.001555063,0.0001829612,0.0004036137,0.0006909065,0.0003050193,0.0006728778,0.001405042],"category_scores_gemma":[0.001626995,0.0002340834,0.0009785052,0.0001938461,0.0002785903,0.0004611759,0.0002427079,0.001504829,0.0002209369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053886,"about_ca_system_score_gemma":0.0004254289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189937,"about_ca_topic_score_gemma":0.003536454,"domain_scores_codex":[0.9996248,0.0001309286,0.00003799086,0.00006707502,0.00004073345,0.00009831682],"domain_scores_gemma":[0.9992251,0.0002974589,0.00009369427,0.00002781981,0.00005830195,0.0002975335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5444451,0.0100024,0.1575704,0.00208318,0.004347789,0.001951201,0.0004351921,0.001406579,0.02045243,0.0002119028,0.004252623,0.2528413],"study_design_scores_gemma":[0.0640274,0.1529298,0.7618459,0.0002598213,0.004498368,0.002576562,0.000650768,0.003302565,0.004048435,0.0001685953,0.005562758,0.0001290311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926122,0.005583751,0.00003479212,0.0002312508,0.0001758951,0.00003531498,0.0001123534,0.00001327199,0.001201322],"genre_scores_gemma":[0.9982986,0.0007766919,0.00008917806,0.0002493043,0.000108526,0.00002179113,0.0001363135,0.000001922739,0.0003175928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555063,"threshold_uncertainty_score":0.004700303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007298984408629103,"score_gpt":0.2890937806489641,"score_spread":0.281794796240335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}