{"id":"W4281698761","doi":"10.1093/nar/gkac489","title":"Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Fundamental Research Funds for the Central Universities; National Medical Research Council; National Natural Science Foundation of China","keywords":"Biology; HIV Long Terminal Repeat; Transcription (linguistics); Repressor; Epigenetics; Long terminal repeat; Viral replication; PRC2; Virus latency; Transcription factor; Cell biology; Virology; Molecular biology; Genetics; Virus; Histone H3; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008408171,0.0002344693,0.0001174754,0.0001455332,0.0001010274,0.0001714749,0.0001408762,0.0001762922,0.001170475],"category_scores_gemma":[0.00008325855,0.00006758064,0.0001382124,0.00005975313,0.0001844816,0.00008950736,0.0001188592,0.0002667023,0.0001679627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038549,"about_ca_system_score_gemma":0.0001597658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005166819,"about_ca_topic_score_gemma":0.001162992,"domain_scores_codex":[0.9999208,0.00001710896,0.000006118536,0.0000106346,0.00002361941,0.00002177442],"domain_scores_gemma":[0.9999669,0.000008699131,0.000008735462,0.000003695752,0.000002337683,0.00000961415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002023285,0.00004393684,0.0002657074,0.00002459566,0.000005046588,0.00004962068,0.00001081085,0.00009348027,0.9960742,0.000153909,0.00006723307,0.003009061],"study_design_scores_gemma":[0.00003503483,0.0006493051,0.003953738,0.000004785541,0.00001212338,0.0001571854,0.00002043505,0.001051209,0.9910387,0.00007323415,0.003000373,0.0000037038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954201,0.00145663,0.001131531,0.0001240859,0.00003219553,0.00001374757,0.0001152107,0.00004944302,0.001657041],"genre_scores_gemma":[0.9969128,0.0004591045,0.0006925346,0.00004778361,0.00001066575,0.000009477323,0.0001881227,0.000004820563,0.001674589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170475,"threshold_uncertainty_score":0.003915668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0406632535437693,"score_gpt":0.3164019435619544,"score_spread":0.2757386900181851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}