{"id":"W4281700822","doi":"10.1101/2022.05.25.493438","title":"Store-Operated Ca 2+ Channels Mediate Microdomain Ca 2+ Signals and Amplify Gq-Coupled Ca 2+ Elevations in Capillary Pericytes","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Lipid microdomain; Pericyte; Cell biology; TRPC3; Calcium signaling; Chemistry; Extracellular; Voltage-dependent calcium channel; Second messenger system; ORAI1; Intracellular; Calcium; Biophysics; Biology; Biochemistry; Receptor; Endothelial stem cell; TRPC; Transient receptor potential channel; Membrane; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046125,0.0002182708,0.000237472,0.0001618195,0.0001200617,0.0002682664,0.0001520623,0.0001916263,0.0009102919],"category_scores_gemma":[0.0001057851,0.00009044006,0.0002138358,0.00009192417,0.0002203409,0.000265436,0.0002005304,0.0004672013,0.000156141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936802,"about_ca_system_score_gemma":0.0001409274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005569588,"about_ca_topic_score_gemma":0.000719915,"domain_scores_codex":[0.9999045,0.000007161982,0.000007181927,0.00001565207,0.00002338686,0.00004213833],"domain_scores_gemma":[0.9999028,0.000014343,0.000022345,0.000007953006,0.00001548469,0.00003709904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000452087,0.000003857202,0.0001191688,0.00001126443,0.000001758575,0.00003899309,0.000007048534,0.000007399717,0.9995291,0.00002560787,0.000008432483,0.0002022044],"study_design_scores_gemma":[0.00002216551,0.0001962483,0.01435418,0.000005422498,0.00001750681,0.0002480478,0.00004281757,0.0006258644,0.9837525,0.0000890392,0.0006426063,0.000003680948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971565,0.0005914813,0.001487877,0.00004563586,0.000008521856,0.00001362021,0.0001390463,0.0000501188,0.0005071374],"genre_scores_gemma":[0.9978006,0.0002530443,0.001150427,0.00003778183,0.000007844304,0.00002005904,0.0001096476,0.00000848725,0.0006120356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009102919,"threshold_uncertainty_score":0.003045201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055296305553099,"score_gpt":0.2367568142113247,"score_spread":0.2162038511557937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}