{"id":"W4281703831","doi":"10.1136/annrheumdis-2021-221801","title":"The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto; Children's Hospital of Western Ontario; Lawson Health Research Institute; Alberta Children's Hospital; Western University","funders":"Chugai Pharmaceutical; EMD Serono; National Institutes of Health; Idorsia Pharmaceuticals; Swedish Orphan Biovitrum; European League Against Rheumatism; Ablynx; Regeneron Pharmaceuticals; Celgene; Biogen; Sanofi; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Rheumatology; Tumor necrosis factor alpha; Internal medicine; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005401729,0.0003545783,0.0007171005,0.0001062865,0.0008047659,0.00003811842,0.001062683,0.00007241125,0.00004318439],"category_scores_gemma":[0.002020907,0.0002237574,0.0004739496,0.000556669,0.001314221,0.0000207441,0.001276707,0.0001471313,6.469903e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006499303,"about_ca_system_score_gemma":0.0003150491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001873588,"about_ca_topic_score_gemma":0.0000498272,"domain_scores_codex":[0.9968005,0.00070438,0.001045054,0.0004323318,0.0005390917,0.0004786233],"domain_scores_gemma":[0.9970577,0.0004364846,0.00132726,0.000765361,0.0003025719,0.0001105942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009613124,0.001799167,0.9592638,0.001657316,0.00207541,0.000004485113,0.002986709,0.0001617271,0.02073651,0.000389174,0.006384082,0.003580329],"study_design_scores_gemma":[0.002490299,0.001298826,0.9411953,0.001646166,0.0005889502,0.00002474027,0.01658005,0.0001113379,0.03389238,0.0003673189,0.001172221,0.0006324208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867601,0.006784038,0.000002189295,0.001330575,0.0004483833,0.001318475,0.003335872,0.00000980645,0.00001057818],"genre_scores_gemma":[0.9967024,0.0026437,0.00002053217,0.00008353974,0.000002759257,0.0003527472,0.00005742467,0.00004012006,0.00009677255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01806849,"threshold_uncertainty_score":0.9124562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232660050692919,"score_gpt":0.2543578670574643,"score_spread":0.2420312665505351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}