{"id":"W4281704677","doi":"10.1007/s40272-022-00515-0","title":"Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced Stevens–Johnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of DEN","year":2022,"lang":"en","type":"review","venue":"Pediatric Drugs","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of British Columbia; Sunnybrook Health Science Centre; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Toxic epidermal necrolysis; Medicine; Dermatology; Mucocutaneous zone; Erythroderma; Differential diagnosis; Drug; Disease; Culprit; Discontinuation; Intensive care medicine; Pathology; Surgery; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004946995,0.0007125034,0.001458169,0.001603086,0.0001578362,0.0007670983,0.0007347829,0.0007058746,0.0015903],"category_scores_gemma":[0.0009795434,0.00020157,0.00069596,0.001079801,0.0002083864,0.0007880048,0.0004837635,0.001306202,0.0005360314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000353994,"about_ca_system_score_gemma":0.0007319961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043812,"about_ca_topic_score_gemma":0.002435022,"domain_scores_codex":[0.9997817,0.00004240457,0.0000530006,0.00003559382,0.00007128943,0.00001600064],"domain_scores_gemma":[0.9996287,0.0001943662,0.00008030195,0.00000642751,0.00006769296,0.00002256412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007617933,0.00005690364,0.0004441862,0.02092288,0.0002327636,0.0003308996,0.00003087236,0.0002752309,0.0007067595,0.0008458488,0.01148621,0.9645911],"study_design_scores_gemma":[0.0001942201,0.0004041725,0.005922165,0.03461143,0.001540083,0.01031171,0.0001701159,0.0004872766,0.000823555,0.002110209,0.9433597,0.00006546212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000128251,0.9993584,0.00007987632,0.00009414577,0.00006229959,0.000003158444,0.000009991898,0.000004206564,0.0002595586],"genre_scores_gemma":[0.001013221,0.9983663,0.0002452688,0.0001458653,0.00009378263,0.000004117539,0.00002717454,8.851302e-7,0.0001033651],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001603086,"threshold_uncertainty_score":0.005320132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0320636901124892,"score_gpt":0.2898885508821817,"score_spread":0.2578248607696925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}