{"id":"W4281704677","doi":"10.1007/s40272-022-00515-0","title":"Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced Stevens–Johnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of DEN","year":2022,"lang":"en","type":"review","venue":"Pediatric Drugs","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of British Columbia; Sunnybrook Health Science Centre; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Toxic epidermal necrolysis; Medicine; Dermatology; Mucocutaneous zone; Erythroderma; Differential diagnosis; Drug; Disease; Culprit; Discontinuation; Intensive care medicine; Pathology; Surgery; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001556642,0.001695358,0.006349776,0.005383992,0.0003251752,0.00008422376,0.000988154,0.0006201544,0.0001570981],"category_scores_gemma":[0.0008959872,0.001796217,0.001718469,0.007584581,0.0000672752,0.0006205741,0.001646936,0.001783812,0.00007065074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001958075,"about_ca_system_score_gemma":0.0007910448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00289426,"about_ca_topic_score_gemma":0.0001504255,"domain_scores_codex":[0.9883956,0.001084433,0.004291977,0.002373019,0.002268877,0.001586107],"domain_scores_gemma":[0.9904528,0.003303205,0.003113037,0.001936216,0.0002852672,0.0009094726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00005245423,0.003209644,0.02866177,0.03093768,0.001925381,0.0009767102,0.001957269,0.00007657205,0.00001209489,0.00001158292,0.0001717691,0.9320071],"study_design_scores_gemma":[0.0313201,0.001828073,0.3379545,0.03725011,0.2423988,0.0006154461,0.01678008,0.0002725822,0.0003671353,0.0001512434,0.315498,0.01556391],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6222336,0.3716596,0.000006155041,0.0001033081,0.0008558502,0.003642906,0.0004025779,0.0001338998,0.0009620474],"genre_scores_gemma":[0.3384562,0.6582234,0.0007298082,0.0000726924,0.0004636791,0.001070164,0.0004730358,0.0003192339,0.0001918515],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9164432,"threshold_uncertainty_score":0.9995793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0320636901124892,"score_gpt":0.2898885508821817,"score_spread":0.2578248607696925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}