{"id":"W4281714381","doi":"10.1200/jco.22.00842","title":"Ciltacabtagene Autoleucel, an Anti–B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":633,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Internal medicine; Refractory (planetary science); Multiple myeloma; Gastroenterology; Cytokine release syndrome; Progression-free survival; Oncology; Chimeric antigen receptor; Surgery; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00212598,0.0002525361,0.0007208618,0.0004187041,0.0003573949,0.0006041339,0.0003253288,0.0003671922,0.0009895703],"category_scores_gemma":[0.0009834751,0.0001252774,0.0007283398,0.0003713937,0.0001750614,0.000465845,0.0002589819,0.0008341367,0.0002722138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006292959,"about_ca_system_score_gemma":0.0005314415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120449,"about_ca_topic_score_gemma":0.001631796,"domain_scores_codex":[0.9995184,0.00010151,0.00004758066,0.00009119987,0.0001413539,0.0001000113],"domain_scores_gemma":[0.9989327,0.0001585203,0.0004192084,0.0001092843,0.0001570516,0.0002233438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05525481,0.003997788,0.628896,0.0004789464,0.002564041,0.001169872,0.0004028591,0.002210798,0.03219574,0.0001495617,0.004664783,0.2680147],"study_design_scores_gemma":[0.003911899,0.03864055,0.9336798,0.00006706706,0.001992753,0.002039201,0.00009214793,0.002022708,0.009924969,0.00009877801,0.007503905,0.00002610275],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921091,0.003406422,0.0007055589,0.0001888605,0.00002793226,0.0001641621,0.0014714,0.00006503437,0.001861557],"genre_scores_gemma":[0.9950839,0.0005209596,0.0002251183,0.0002629704,0.00003178474,0.00005930514,0.003024408,0.000007514979,0.0007839283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212598,"threshold_uncertainty_score":0.0112434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053813735833881,"score_gpt":0.4275996332850936,"score_spread":0.3222182597017055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}