{"id":"W4281714381","doi":"10.1200/jco.22.00842","title":"Ciltacabtagene Autoleucel, an Anti–B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":633,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Internal medicine; Refractory (planetary science); Multiple myeloma; Gastroenterology; Cytokine release syndrome; Progression-free survival; Oncology; Chimeric antigen receptor; Surgery; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006861262,0.0003432141,0.001980298,0.0003779603,0.0003750529,0.00004230504,0.0006530831,0.0005373737,0.004189357],"category_scores_gemma":[0.00119618,0.0002896674,0.001140627,0.0004487903,0.0002323995,0.0003187422,0.0001751996,0.002321329,0.00005448308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658435,"about_ca_system_score_gemma":0.003074835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004532814,"about_ca_topic_score_gemma":0.00002323575,"domain_scores_codex":[0.9931665,0.001574675,0.002788658,0.0005926219,0.001194252,0.0006832584],"domain_scores_gemma":[0.9935372,0.002158103,0.00213883,0.0006356935,0.000820089,0.0007101148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04370902,0.00835889,0.0572143,0.00007416298,0.0006110329,0.0003038065,0.0008911008,0.0001305585,0.7406034,0.00001166397,0.03357917,0.1145129],"study_design_scores_gemma":[0.04173625,0.04750365,0.08018192,0.00002589242,0.0001660369,0.0001637044,0.0008610908,0.0006464586,0.01906875,0.00005061588,0.8092293,0.0003663344],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877518,0.001820263,0.0002293019,0.002171722,0.00455906,0.001344877,0.00004677721,0.00005148336,0.002024681],"genre_scores_gemma":[0.9775819,0.005032242,0.005973665,0.001573749,0.002743393,0.00005958544,0.0001068133,0.0001235162,0.006805128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7756501,"threshold_uncertainty_score":0.9999803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053813735833881,"score_gpt":0.4275996332850936,"score_spread":0.3222182597017055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}