{"id":"W4281715961","doi":"10.1038/s41556-022-00913-z","title":"Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis","year":2022,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; National Supercomputing Centre Singapore; Cancer Science Institute of Singapore, National University of Singapore; Ministry of Education, India; National University Health System; National Research Foundation; Ministry of Education - Singapore; National Medical Research Council; National Research Foundation Singapore; King Abdullah University of Science and Technology","keywords":"RNA splicing; Alternative splicing; Three prime untranslated region; Untranslated region; Biology; Downregulation and upregulation; Polyadenylation; Five prime untranslated region; Cancer research; RNA-binding protein; Messenger RNA; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141473,0.0002205649,0.0002795151,0.0003272459,0.0001908137,0.0004308377,0.00009935632,0.000217533,0.001617739],"category_scores_gemma":[0.0001379941,0.0001635885,0.0002570675,0.0002945407,0.0002578225,0.0001432716,0.0002701519,0.0004008462,0.0006314002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331992,"about_ca_system_score_gemma":0.0002202344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006502446,"about_ca_topic_score_gemma":0.001297142,"domain_scores_codex":[0.9998386,0.00001818484,0.00001231174,0.00005103938,0.00005283123,0.0000271026],"domain_scores_gemma":[0.9998472,0.00002746945,0.00005439502,0.00001967021,0.00001980429,0.00003153891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003293698,0.000006200893,0.0008546191,0.00002299532,0.000004250289,0.00006889561,0.00001138453,0.00007396573,0.9972582,0.0001376377,0.00005598193,0.001472889],"study_design_scores_gemma":[0.000008591364,0.0002478415,0.05024439,0.00001385058,0.00003472154,0.001440269,0.0000845668,0.002141143,0.9352868,0.0003591324,0.01012838,0.00001042969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826205,0.002629181,0.008892144,0.0001341438,0.00003482879,0.00002921143,0.001048714,0.0005277059,0.004083508],"genre_scores_gemma":[0.9920691,0.001337204,0.003065431,0.00007975497,0.000007915609,0.00002367814,0.001001272,0.00008276384,0.002332833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617739,"threshold_uncertainty_score":0.005411863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006299910673211465,"score_gpt":0.2763293175871684,"score_spread":0.2700294069139569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}