{"id":"W4281719414","doi":"10.1093/genetics/iyac092","title":"Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University at Buffalo","keywords":"DNA mismatch repair; MSH2; Biology; Genetics; Mutation; DNA repair; Ribonucleotide reductase; MSH6; Postreplication repair; Mutagenesis; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151182,0.0002157767,0.0001792454,0.0003770535,0.00008996559,0.000211341,0.0001280382,0.0002301213,0.0007120431],"category_scores_gemma":[0.0001806539,0.0001244405,0.0001731643,0.000168439,0.0001236111,0.0001307014,0.0001980238,0.0002346283,0.0002030625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227315,"about_ca_system_score_gemma":0.00005536002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005193902,"about_ca_topic_score_gemma":0.0008157126,"domain_scores_codex":[0.9998527,0.00001515711,0.00001643297,0.00005264121,0.00004130773,0.00002174527],"domain_scores_gemma":[0.9998337,0.00002977819,0.00005949703,0.00001800319,0.00002409945,0.00003491771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004457063,0.000005832288,0.001302034,0.000008136074,0.000006594067,0.00001977431,0.0000131226,0.00006529833,0.9979195,0.00003076835,0.00001010643,0.0005743385],"study_design_scores_gemma":[0.000004389571,0.0001421807,0.03799682,0.000002804223,0.00002195108,0.000555375,0.00003851909,0.00263992,0.9577659,0.0001348602,0.0006901176,0.000007130381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967936,0.0002718505,0.002317731,0.00001820656,0.00000385696,0.000008699954,0.0002725553,0.00004859298,0.0002650069],"genre_scores_gemma":[0.9967006,0.00008012846,0.002295707,0.00002350898,0.000001420161,0.000005998565,0.0003198412,0.00002431494,0.0005486123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007120431,"threshold_uncertainty_score":0.00238198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04490010353489905,"score_gpt":0.2879934443569774,"score_spread":0.2430933408220784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}