{"id":"W4281723561","doi":"10.1016/j.canlet.2022.215765","title":"Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma","year":2022,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aptose Biosciences (Canada); Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Région Normandie; Ligue Contre le Cancer; Université de Strasbourg; Lundbeckfonden; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Exocytosis; Pheochromocytoma; Catecholamine; Secretion; Adrenal medulla; Endocrinology; Internal medicine; Chromaffin cell; Calcium; Biology; Cancer research; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717798,0.0002946148,0.0004664769,0.0004611298,0.000427283,0.0006356939,0.0003288877,0.001607033,0.00115374],"category_scores_gemma":[0.001948784,0.0001708931,0.0002978264,0.0003775258,0.0004166847,0.0004697534,0.0001962066,0.0009515138,0.000316646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004379283,"about_ca_system_score_gemma":0.000251423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008941176,"about_ca_topic_score_gemma":0.0007158353,"domain_scores_codex":[0.9998092,0.00001956669,0.00003269613,0.00004505839,0.00004078956,0.00005273278],"domain_scores_gemma":[0.9993358,0.0003103437,0.000090426,0.00004728534,0.00008068037,0.0001354682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.002504478,0.0001414895,0.3707237,0.0001231566,0.00008116855,0.5691826,0.0004822836,0.0002599141,0.03302128,0.0005439842,0.004156773,0.01877909],"study_design_scores_gemma":[0.0001516036,0.0006126277,0.3773623,0.00003769266,0.0001459722,0.6019126,0.0006212742,0.002393432,0.01063462,0.00110749,0.004971353,0.00004903268],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898925,0.001664643,0.0006160651,0.004589736,0.0003487095,0.00001295583,0.0001215857,0.000062694,0.002691224],"genre_scores_gemma":[0.9985332,0.0002576809,0.00009809741,0.0004382101,0.0003635454,0.000002720522,0.00003860961,0.00000553867,0.0002623488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607033,"threshold_uncertainty_score":0.003859639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02826828432105263,"score_gpt":0.2288302145645291,"score_spread":0.2005619302434765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}