{"id":"W4281723561","doi":"10.1016/j.canlet.2022.215765","title":"Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma","year":2022,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aptose Biosciences (Canada); Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Région Normandie; Ligue Contre le Cancer; Université de Strasbourg; Lundbeckfonden; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Exocytosis; Pheochromocytoma; Catecholamine; Secretion; Adrenal medulla; Endocrinology; Internal medicine; Chromaffin cell; Calcium; Biology; Cancer research; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006827027,0.0001526671,0.0002647272,0.0001846403,0.0000877432,0.000003565972,0.00006303292,0.00003597376,0.0005101961],"category_scores_gemma":[0.00000824256,0.0001317766,0.0000516285,0.0004749759,0.00008191206,0.0000656054,0.00005298433,0.0001895055,0.000005407698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009346953,"about_ca_system_score_gemma":0.00006929736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004772734,"about_ca_topic_score_gemma":0.0000985012,"domain_scores_codex":[0.9988433,0.00005070366,0.0002358381,0.0002675739,0.0003812168,0.0002213289],"domain_scores_gemma":[0.9995103,0.00002098959,0.0001535339,0.0001894075,0.00006106258,0.00006468098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008512083,0.001166114,0.5009267,0.0003334378,0.0001572138,0.0008646236,0.001899382,0.004952436,0.475297,0.000005281284,0.004486116,0.001399633],"study_design_scores_gemma":[0.01007018,0.001290248,0.8036175,0.0001707436,0.0001831953,0.0001506347,0.0001622062,0.0001282465,0.1831927,0.000001218645,0.0007353738,0.0002977267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983881,0.0001161158,0.00007306613,0.0006784329,0.0001686371,0.0003657515,0.0000829817,0.00003458131,0.0000923519],"genre_scores_gemma":[0.9980173,0.000001213284,0.00004352011,0.001084827,0.00004478191,0.00008955803,0.0002240254,0.00002857293,0.0004662461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3026909,"threshold_uncertainty_score":0.558629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02826828432105263,"score_gpt":0.2288302145645291,"score_spread":0.2005619302434765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}