{"id":"W4281724669","doi":"10.1200/jco.2022.40.16_suppl.3573","title":"Pembrolizumab (pembro) plus binimetinib (bini) with or without chemotherapy (chemo) for metastatic colorectal cancer (mCRC): Results from KEYNOTE-651 cohorts A, C, and E.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Centre Hospitalier de l’Université de Montréal; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Cohort; Medicine; Oxaliplatin; Colorectal cancer; Pembrolizumab; Irinotecan; Oncology; FOLFIRI; Internal medicine; Cancer; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001634776,0.0008770186,0.001164059,0.0004441894,0.0003772232,0.0006975217,0.0007055152,0.0008912986,0.003360661],"category_scores_gemma":[0.000777553,0.0003620624,0.001185734,0.0006444335,0.0005429178,0.0007665835,0.0005227973,0.00181697,0.0005885039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00122005,"about_ca_system_score_gemma":0.001675788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00329064,"about_ca_topic_score_gemma":0.009178924,"domain_scores_codex":[0.9994541,0.0002334983,0.00003881882,0.00009351272,0.00005312547,0.0001269014],"domain_scores_gemma":[0.9992132,0.0001144455,0.0001470456,0.00006148885,0.00004007434,0.0004238294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8491001,0.04483337,0.0104532,0.001009339,0.002098163,0.0001592254,0.0001937546,0.001618207,0.01447446,0.0001722121,0.004411488,0.07147647],"study_design_scores_gemma":[0.4141175,0.524239,0.05011024,0.0001219941,0.002136516,0.0003059416,0.0001384657,0.0007306963,0.003491525,0.0001303937,0.0044397,0.00003806989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990577,0.002881923,0.0002437789,0.0002828157,0.00007072315,0.001324808,0.00257437,0.00003860245,0.002006039],"genre_scores_gemma":[0.9874478,0.002591514,0.0008028034,0.0006186698,0.0001088914,0.0008749849,0.005765161,0.00001561259,0.001774588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003360661,"threshold_uncertainty_score":0.01124251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1216480759412917,"score_gpt":0.4555265540163738,"score_spread":0.3338784780750821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}