{"id":"W4281724946","doi":"10.2196/37275","title":"Bronchopulmonary Penetration of Isavuconazole in Pulmonary Transplant Recipients (PBISA01): Protocol for a Phase IV Clinical Trial With a Single Treatment Arm","year":2022,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Bronchoalveolar lavage; Lung transplantation; Bronchoscopy; Voriconazole; Clinical trial; Lung; Surgery; Internal medicine; Dermatology; Antifungal","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01145715,0.004550903,0.005844497,0.001135851,0.002350341,0.002546547,0.003640405,0.005743225,0.03395265],"category_scores_gemma":[0.009018494,0.00194751,0.002834417,0.001367945,0.002703052,0.00217632,0.001580244,0.008455023,0.009311694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002774806,"about_ca_system_score_gemma":0.01020051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035063,"about_ca_topic_score_gemma":0.00289921,"domain_scores_codex":[0.9948316,0.002898578,0.0003538587,0.0005580676,0.0005881421,0.0007697574],"domain_scores_gemma":[0.9947477,0.0005428654,0.001100376,0.0008497154,0.001021966,0.001737396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9083655,0.032161,0.0007932978,0.004214799,0.0008381951,0.0002148507,0.0002188431,0.00190745,0.009187421,0.001633829,0.0143883,0.02607644],"study_design_scores_gemma":[0.8976237,0.07277063,0.00156229,0.000562266,0.0003648014,0.0001059887,0.00005753014,0.0009264043,0.001248294,0.00102863,0.02368668,0.00006271187],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02444833,0.0009670578,0.003281313,0.0007471222,0.0006437851,0.9626275,0.003616801,0.0002835948,0.003384551],"genre_scores_gemma":[0.01853801,0.0005620457,0.004013932,0.0005949898,0.0001679403,0.9731265,0.001063875,0.00001999091,0.001912771],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03395265,"threshold_uncertainty_score":0.113583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5071444129909064,"score_gpt":0.6184405404768867,"score_spread":0.1112961274859803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}