{"id":"W4281726288","doi":"10.3389/fphys.2022.892979","title":"Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction","year":2022,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Skeletal muscle; Troponin; Myosin; Actin; Cardiac muscle; Troponin I; Troponin C; Troponin complex; Chemistry; Troponin T; Calcium; Biophysics; Isometric exercise; Muscle contraction; Contraction (grammar); Internal medicine; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258334,0.0004360238,0.0004503278,0.0002164227,0.0001279988,0.0002173174,0.0004753613,0.000445912,0.00170984],"category_scores_gemma":[0.0001932049,0.0002131427,0.0004517807,0.000112876,0.0002468525,0.0001689966,0.0002137479,0.0006757508,0.0004153647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248836,"about_ca_system_score_gemma":0.0001299602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001386918,"about_ca_topic_score_gemma":0.0001921511,"domain_scores_codex":[0.9998744,0.0000247065,0.00001228581,0.00002964136,0.00003306366,0.00002601426],"domain_scores_gemma":[0.9998788,0.00003844346,0.00003283242,0.00001155572,0.00001207828,0.00002636358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314589,0.00005833092,0.00006038802,0.00004188617,0.00001066302,0.00003497665,0.000006888867,0.0001677797,0.9984468,0.00006255202,0.00003078506,0.0009475974],"study_design_scores_gemma":[0.0001573276,0.001437088,0.001007372,0.000007068932,0.0000338869,0.0001283481,0.000006385433,0.001144936,0.9941514,0.00003089161,0.001886152,0.000009095953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902006,0.001745816,0.005951699,0.0001512406,0.00007072885,0.0001675202,0.0002375945,0.0001682662,0.001306592],"genre_scores_gemma":[0.9874092,0.001020286,0.008703158,0.0001586875,0.00003177209,0.0001572689,0.0004736613,0.00002921616,0.002016797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170984,"threshold_uncertainty_score":0.005720019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919830609778951,"score_gpt":0.253902983560371,"score_spread":0.2347046774625815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}