{"id":"W4281731883","doi":"10.1093/neuonc/noac079.116","title":"DIPG-59. Blood Brain Barrier (BBB) modulation using Cadherin peptides in the treatment of Diffuse Midline Glioma of the Pons (DMG-P)","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Manitoba","funders":"","keywords":"In vitro; Blood–brain barrier; Glioma; Chemistry; Tight junction; Cancer research; Permeability (electromagnetism); Brainstem; In vivo; Biophysics; Pathology; Pharmacology; Medicine; Central nervous system; Biochemistry; Biology; Internal medicine; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007542782,0.0002438633,0.0002204018,0.0001500589,0.00007617799,0.0001425967,0.0001574481,0.0002038905,0.0008186256],"category_scores_gemma":[0.00005577286,0.00005220889,0.0001430034,0.0001231871,0.0001093554,0.0001160171,0.0001016021,0.0004214945,0.0001653159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786767,"about_ca_system_score_gemma":0.0001687654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006400302,"about_ca_topic_score_gemma":0.0009260327,"domain_scores_codex":[0.9999554,0.000006377192,0.000002834564,0.000007828073,0.0000140339,0.00001346014],"domain_scores_gemma":[0.9999796,0.000002330954,0.000005015714,0.000001591743,0.000003285056,0.000008132229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007591749,0.0003312982,0.0003140557,0.0003955537,0.00001997254,0.0002859531,0.00002392626,0.0002067111,0.9806692,0.00012114,0.0002986825,0.01657426],"study_design_scores_gemma":[0.0002464551,0.008995137,0.007287079,0.00002410896,0.00008088975,0.001233003,0.00003702597,0.0008010652,0.9723588,0.00005246532,0.008875981,0.000008087312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893646,0.007393427,0.001239015,0.0001003285,0.00006943968,0.000102344,0.0002641712,0.00008586194,0.001380716],"genre_scores_gemma":[0.9943764,0.002705059,0.001434822,0.00005165974,0.00001037369,0.00004952892,0.0003291852,0.000006700083,0.001036268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008186256,"threshold_uncertainty_score":0.002738595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03257286863052938,"score_gpt":0.3068318214457421,"score_spread":0.2742589528152127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}