{"id":"W4281731899","doi":"10.1007/s13555-022-00743-9","title":"Safety of Ixekizumab in Adult Patients with Moderate-to-Severe Psoriasis: Data from 17 Clinical Trials with Over 18,000 Patient-Years of Exposure","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Eli Lilly and Company","keywords":"Medicine; Ixekizumab; Adverse effect; Internal medicine; Discontinuation; Psoriasis; Incidence (geometry); Mace; Psoriatic arthritis; Gastroenterology; Pediatrics; Disease; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004264544,0.0002192101,0.001060585,0.0001384056,0.0001177271,0.00000441136,0.0003272802,0.0002355705,0.0006732741],"category_scores_gemma":[0.00007132087,0.0001640552,0.00006892947,0.0001866799,0.000184371,0.0001008259,0.0001535986,0.0002405045,0.000004843084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227828,"about_ca_system_score_gemma":0.000086392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075795,"about_ca_topic_score_gemma":0.0001168324,"domain_scores_codex":[0.9964147,0.00186662,0.0008914903,0.000494519,0.00008452332,0.0002481657],"domain_scores_gemma":[0.9979808,0.0008240175,0.0004676182,0.0006169106,0.00007732737,0.00003328416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07342228,0.001500472,0.8201066,0.00001112884,0.001755168,0.00004325357,0.001697537,0.00005933881,0.000233275,0.00009970344,0.00139276,0.0996785],"study_design_scores_gemma":[0.05519511,0.002859558,0.9308409,0.0000702055,0.0002635403,0.00006535341,0.000733179,0.00001409785,0.002323285,0.0001747078,0.007049749,0.0004103025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993553,0.002686065,0.00001729527,0.00007138703,0.0003023978,0.0006167968,0.00266907,0.00001569353,0.00006823395],"genre_scores_gemma":[0.9971169,0.000661632,0.000135634,0.000316884,0.00001044753,0.00006573524,0.001647797,0.00001967685,0.00002528509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1107343,"threshold_uncertainty_score":0.7371879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04291786035963877,"score_gpt":0.2959033773136925,"score_spread":0.2529855169540538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}