{"id":"W4281731899","doi":"10.1007/s13555-022-00743-9","title":"Safety of Ixekizumab in Adult Patients with Moderate-to-Severe Psoriasis: Data from 17 Clinical Trials with Over 18,000 Patient-Years of Exposure","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Eli Lilly and Company","keywords":"Medicine; Ixekizumab; Adverse effect; Internal medicine; Discontinuation; Psoriasis; Incidence (geometry); Mace; Psoriatic arthritis; Gastroenterology; Pediatrics; Disease; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008763782,0.0005689239,0.001851846,0.0005321491,0.0002440228,0.001027039,0.0003989964,0.0006286483,0.002542714],"category_scores_gemma":[0.008182413,0.0003012217,0.00331797,0.00117088,0.0003816017,0.0006820592,0.0004278908,0.0008571277,0.0002741458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462733,"about_ca_system_score_gemma":0.0006725152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065032,"about_ca_topic_score_gemma":0.0005252155,"domain_scores_codex":[0.9953637,0.002046509,0.001201944,0.0004838581,0.0007257945,0.0001780734],"domain_scores_gemma":[0.9854113,0.005950222,0.007044028,0.0006067883,0.0006368785,0.0003508778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2419831,0.002238929,0.2963886,0.03321084,0.08190615,0.0006209846,0.0003326406,0.004281146,0.01088818,0.0003450382,0.005352349,0.322452],"study_design_scores_gemma":[0.142415,0.1281875,0.5843183,0.006361311,0.0866502,0.004544382,0.0002545702,0.00156357,0.00728616,0.001104814,0.0371648,0.0001493787],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7789466,0.2086251,0.001518928,0.0008266288,0.0001023201,0.00100765,0.005735019,0.00006545426,0.003172259],"genre_scores_gemma":[0.9496013,0.04279735,0.001218165,0.0007181578,0.000283211,0.0007524084,0.00420212,0.00001559447,0.0004116057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008763782,"threshold_uncertainty_score":0.04634786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04291786035963877,"score_gpt":0.2959033773136925,"score_spread":0.2529855169540538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}