{"id":"W4281737483","doi":"10.1212/wnl.0000000000200715","title":"Natural History Study of STXBP1-Developmental and Epileptic Encephalopathy Into Adulthood","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"UCB Pharma; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Novartis Pharma; Perelman School of Medicine, University of Pennsylvania; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; H. Lundbeck A/S; Vlaamse regering; Eisai; Lundbeckfonden; Bundesministerium für Bildung und Forschung; Zynerba Pharmaceuticals; National Institute of Child Health and Human Development; Sanofi; GW Pharmaceuticals; Arvelle Therapeutics; GlaxoSmithKline; LivaNova; Deutsche Forschungsgemeinschaft; Ultragenyx Pharmaceutical; Wellcome Trust; Zogenix; Angelini Pharma; Ministero dell’Istruzione, dell’Università e della Ricerca; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Institute for Translational Medicine and Therapeutics; Novo Nordisk Fonden; Children's Hospital of Philadelphia; University of Pennsylvania","keywords":"Natural history; Epilepsy; Neuroscience; Encephalopathy; Medicine; Psychology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276903,0.0002221042,0.0002529453,0.0007124769,0.0005478554,0.0003791051,0.0001741092,0.0003539047,0.001162171],"category_scores_gemma":[0.001173819,0.000151114,0.0002059243,0.0005476781,0.0002177665,0.0005315961,0.0003771535,0.0003702027,0.0002247903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512618,"about_ca_system_score_gemma":0.000215214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00230828,"about_ca_topic_score_gemma":0.002152186,"domain_scores_codex":[0.999797,0.00003133383,0.00002354826,0.00006339732,0.0000304099,0.00005424367],"domain_scores_gemma":[0.9991564,0.00009261664,0.0003635484,0.0000352043,0.0001005049,0.0002517865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001102303,0.00004067333,0.9960964,0.000003590102,0.000008056427,0.001227312,0.0001771133,0.00001517719,0.0004088579,0.00001845892,0.00006090988,0.001833151],"study_design_scores_gemma":[0.000005126365,0.0002538817,0.9928555,0.000005356356,0.000009739206,0.006226583,0.0002130727,0.0000666761,0.0001050362,0.00003055896,0.0002252188,0.000003252334],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994279,0.0001204821,0.00003832486,0.0000188405,0.00000161103,0.000004502628,0.0001414788,0.000002216897,0.0002445932],"genre_scores_gemma":[0.9993629,0.00007749331,0.00005181215,0.00001794566,0.000005589418,0.000004931224,0.0003347498,0.000001586837,0.000142994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00230828,"threshold_uncertainty_score":0.004589736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516011207859109,"score_gpt":0.2627930465830531,"score_spread":0.2476329345044621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}