{"id":"W4281737483","doi":"10.1212/wnl.0000000000200715","title":"Natural History Study of STXBP1-Developmental and Epileptic Encephalopathy Into Adulthood","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"UCB Pharma; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Novartis Pharma; Perelman School of Medicine, University of Pennsylvania; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; H. Lundbeck A/S; Vlaamse regering; Eisai; Lundbeckfonden; Bundesministerium für Bildung und Forschung; Zynerba Pharmaceuticals; National Institute of Child Health and Human Development; Sanofi; GW Pharmaceuticals; Arvelle Therapeutics; GlaxoSmithKline; LivaNova; Deutsche Forschungsgemeinschaft; Ultragenyx Pharmaceutical; Wellcome Trust; Zogenix; Angelini Pharma; Ministero dell’Istruzione, dell’Università e della Ricerca; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Institute for Translational Medicine and Therapeutics; Novo Nordisk Fonden; Children's Hospital of Philadelphia; University of Pennsylvania","keywords":"Natural history; Epilepsy; Neuroscience; Encephalopathy; Medicine; Psychology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128875,0.00009199061,0.0002267767,0.0001059606,0.00008095145,0.000001163316,0.00007306554,0.00002232414,0.0004334954],"category_scores_gemma":[0.00005143487,0.00008136615,0.00002686409,0.00007949348,0.00009373579,0.00002227426,0.0002018038,0.0003578289,0.000007489175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001309675,"about_ca_system_score_gemma":0.0001486139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001519634,"about_ca_topic_score_gemma":0.00009984106,"domain_scores_codex":[0.9988972,0.0002019822,0.0001722118,0.0002699536,0.0002657055,0.0001929466],"domain_scores_gemma":[0.9996052,0.00007903873,0.00004626513,0.0001410792,0.00003175233,0.00009667234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00326727,0.002825988,0.9622952,0.00004878825,0.0001441549,0.001826138,0.009508097,0.000001153105,0.006245873,0.00005613802,0.001221512,0.01255969],"study_design_scores_gemma":[0.005030979,0.02639667,0.9620505,0.000002225056,0.00005002139,0.0005552564,0.001338217,0.00005007223,0.00006873595,0.00005429861,0.004323476,0.00007952133],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971205,0.001162066,2.763098e-7,0.0005070842,0.0002292484,0.0004598527,0.000002097276,0.00002121083,0.0004976892],"genre_scores_gemma":[0.9988745,0.00003782844,0.00009227879,0.0006873151,0.00002372249,0.0001168957,0.00001034705,0.00001131365,0.0001457599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02357068,"threshold_uncertainty_score":0.474647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516011207859109,"score_gpt":0.2627930465830531,"score_spread":0.2476329345044621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}