{"id":"W4281750499","doi":"10.1200/jco.2022.40.16_suppl.5039","title":"Candidate surrogate endpoints in advanced prostate cancer: Aggregate meta-analysis of 143 randomized trials.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institutes of Health; Prostate Cancer Foundation","keywords":"Medicine; Prostate cancer; Internal medicine; Clinical endpoint; Hazard ratio; Oncology; Randomized controlled trial; Surrogate endpoint; Progression-free survival; Prostate; Urology; Cancer; Confidence interval; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04247535,0.003021188,0.01376844,0.003827188,0.0005358214,0.003353009,0.001655093,0.002240254,0.006126406],"category_scores_gemma":[0.05852033,0.001601736,0.04826893,0.006415087,0.0007058642,0.001878667,0.001743298,0.00272466,0.0008230504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001521298,"about_ca_system_score_gemma":0.002009653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002573912,"about_ca_topic_score_gemma":0.005027825,"domain_scores_codex":[0.9553685,0.03424817,0.005593822,0.002569689,0.00173276,0.0004871042],"domain_scores_gemma":[0.966382,0.02752792,0.003550194,0.001502229,0.0007585966,0.000279156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01145138,0.00003008026,0.004352211,0.04928336,0.9266751,0.00007868729,0.00003130275,0.001775073,0.0002046568,0.0002195961,0.0007920705,0.005106479],"study_design_scores_gemma":[0.004677354,0.0003782231,0.002839522,0.00251333,0.9866046,0.00006755885,0.00001945719,0.0007054933,0.0001190799,0.0005724627,0.001483308,0.00001951001],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03699401,0.9334598,0.01403461,0.0007264125,0.0006125109,0.002650358,0.009347161,0.0003095071,0.001865631],"genre_scores_gemma":[0.7723296,0.1885567,0.01740818,0.00198611,0.0004944589,0.01027829,0.007312492,0.0002029754,0.001431182],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04247535,"threshold_uncertainty_score":0.2246339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.308102239375477,"score_gpt":0.5556795685582354,"score_spread":0.2475773291827584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}