{"id":"W4281750600","doi":"10.1001/jamapsychiatry.2022.1391","title":"Combination Antidepressant Therapy vs Monotherapy—Further Considerations","year":2022,"lang":"en","type":"letter","venue":"JAMA Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001934698,0.000579465,0.0007337842,0.0004213005,0.0003354374,0.0001468676,0.0002118016,0.0009243361,0.01116146],"category_scores_gemma":[0.00003994499,0.0004953865,0.0004244487,0.0002084816,0.00008980529,0.000178681,0.0000661549,0.002545624,0.0001576497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802596,"about_ca_system_score_gemma":0.0004270691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008339067,"about_ca_topic_score_gemma":0.000007349236,"domain_scores_codex":[0.9968106,0.000320885,0.000580869,0.0008369591,0.0009975097,0.0004532162],"domain_scores_gemma":[0.9978918,0.0002194414,0.0004192739,0.001248765,0.0001252472,0.00009546567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005416102,0.0007525943,0.01724724,0.0001032884,0.0005414278,0.0003096117,0.0002189428,0.000003712398,0.00008682939,0.0002048263,0.9774678,0.00252211],"study_design_scores_gemma":[0.01148576,0.001099154,0.02163531,0.0002275834,0.0002407751,0.0003129515,0.00005292211,0.00003714271,0.0001096263,0.004630767,0.959664,0.0005039559],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01406396,0.005806759,0.00002966259,0.9659295,0.003808007,0.001674101,0.0001526908,0.0004110921,0.008124215],"genre_scores_gemma":[0.01450758,0.001227111,0.002532979,0.9659305,0.005257978,0.0004872415,0.002075386,0.0002997014,0.007681479],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01780376,"threshold_uncertainty_score":0.9997556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222039678408074,"score_gpt":0.2805970477391008,"score_spread":0.2583766509550201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}