{"id":"W4281753784","doi":"10.3389/fviro.2022.894531","title":"Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody Escape","year":2022,"lang":"en","type":"article","venue":"Frontiers in Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; New York University Abu Dhabi","keywords":"Chemistry; Antibody; Electrostatics; Static electricity; Prion protein; Biophysics; Receptor; Biology; Biochemistry; Physics; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195836,0.0002925202,0.0002151385,0.0001216249,0.000197597,0.0002775498,0.0001887136,0.0002814576,0.0007725588],"category_scores_gemma":[0.0001815938,0.0001099324,0.0003407407,0.0001225063,0.0001923788,0.0001852938,0.0003335229,0.0003317685,0.0002139408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003370177,"about_ca_system_score_gemma":0.0002141884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162991,"about_ca_topic_score_gemma":0.001588959,"domain_scores_codex":[0.9998639,0.00001619731,0.000007046122,0.0000215539,0.00006056192,0.00003083342],"domain_scores_gemma":[0.9999243,0.00001178166,0.00002905123,0.000006690589,0.00001514027,0.00001298338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000730617,0.00003331418,0.006542186,0.00004139813,0.00001949222,0.0002747647,0.0000218992,0.001509282,0.9870375,0.0003143764,0.0001482022,0.003984407],"study_design_scores_gemma":[0.00002034905,0.00034272,0.03499377,0.00001069448,0.00003354777,0.001553091,0.0001402871,0.02944703,0.9303714,0.0004041433,0.002666669,0.0000163768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931987,0.0002024715,0.00522389,0.00006316972,0.000007385271,0.000009281864,0.00006963211,0.00006034616,0.001165114],"genre_scores_gemma":[0.9966455,0.00008503193,0.002654672,0.00005810011,0.000002480197,0.000004798473,0.0001623721,0.00001320632,0.000373771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162991,"threshold_uncertainty_score":0.002584517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978421659069441,"score_gpt":0.2993681793150408,"score_spread":0.2695839627243464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}