{"id":"W4281755040","doi":"10.1200/jco.2022.40.16_suppl.1052","title":"Long-term safety of inavolisib (GDC-0077) in an ongoing phase 1/1b study evaluating monotherapy and in combination (combo) with palbociclib and/or endocrine therapy in patients (pts) with <i>PIK3CA</i>-mutated, hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (BC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genentech","keywords":"Medicine; Neutropenia; Adverse effect; Internal medicine; Letrozole; Gastroenterology; Toxicity; Phases of clinical research; Palbociclib; Fulvestrant; Common Terminology Criteria for Adverse Events; Pharmacology; Oncology; Cancer; Tamoxifen; Breast cancer; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001929356,0.00117618,0.001610691,0.0005684586,0.0003829005,0.001260096,0.001047332,0.00128344,0.004387987],"category_scores_gemma":[0.00102444,0.0004887289,0.001085338,0.0005197077,0.001000177,0.001058473,0.000412137,0.003387609,0.001420506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001386401,"about_ca_system_score_gemma":0.002102607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152947,"about_ca_topic_score_gemma":0.004190687,"domain_scores_codex":[0.9995521,0.0001994576,0.00002077772,0.00007832624,0.00005082384,0.00009851369],"domain_scores_gemma":[0.9992344,0.0001092436,0.0001449396,0.00005592968,0.000058128,0.0003973135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7016795,0.07107352,0.009582143,0.001162229,0.00168781,0.0002611058,0.0003657631,0.003777213,0.04175535,0.000537722,0.008467699,0.15965],"study_design_scores_gemma":[0.4264359,0.5405923,0.01677717,0.00008581472,0.0008440572,0.0004241749,0.0001110051,0.001585763,0.005222772,0.0003280667,0.007544663,0.00004828243],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869465,0.003107686,0.0005993041,0.0004333169,0.0001293028,0.002315941,0.00228852,0.0001621375,0.004017217],"genre_scores_gemma":[0.9812325,0.002293847,0.001682545,0.001115252,0.0001725006,0.002261229,0.006526463,0.00006419791,0.004651439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004387987,"threshold_uncertainty_score":0.01467925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07703013949222451,"score_gpt":0.4674175886751332,"score_spread":0.3903874491829087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}