{"id":"W4281755040","doi":"10.1200/jco.2022.40.16_suppl.1052","title":"Long-term safety of inavolisib (GDC-0077) in an ongoing phase 1/1b study evaluating monotherapy and in combination (combo) with palbociclib and/or endocrine therapy in patients (pts) with <i>PIK3CA</i>-mutated, hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (BC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genentech","keywords":"Medicine; Neutropenia; Adverse effect; Internal medicine; Letrozole; Gastroenterology; Toxicity; Phases of clinical research; Palbociclib; Fulvestrant; Common Terminology Criteria for Adverse Events; Pharmacology; Oncology; Cancer; Tamoxifen; Breast cancer; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003238021,0.0003313525,0.002019322,0.0004608712,0.00008174864,0.00001451691,0.000177675,0.00008718391,0.0001033997],"category_scores_gemma":[0.0002531321,0.0002291903,0.00007596645,0.0007335542,0.0003572513,0.000497002,0.00007350367,0.001349484,1.224042e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007756522,"about_ca_system_score_gemma":0.000954871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008936198,"about_ca_topic_score_gemma":0.003607215,"domain_scores_codex":[0.9936648,0.002371776,0.002369221,0.000467103,0.0007572152,0.000369861],"domain_scores_gemma":[0.9948739,0.001891135,0.002232759,0.0002024841,0.0005866567,0.0002130389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1598169,0.01752114,0.577219,0.00002149587,0.0003304161,0.0002896052,0.003387786,0.0005180744,0.0001968498,0.000002334897,0.000001171236,0.2406952],"study_design_scores_gemma":[0.1794374,0.1049135,0.7110791,0.0003335807,0.0001183742,0.000158502,0.003265247,0.0004029132,0.00006086985,0.00004599214,0.000008537883,0.000176029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962423,0.0005208917,0.00007789389,0.001155722,0.0001069169,0.001834661,0.00004159223,0.000008623992,0.00001135696],"genre_scores_gemma":[0.9958478,0.00138545,0.00199174,0.0004967113,0.00006902681,0.0001283647,0.00001554361,0.0000562639,0.000009095041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2405192,"threshold_uncertainty_score":0.9346111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07703013949222451,"score_gpt":0.4674175886751332,"score_spread":0.3903874491829087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}