{"id":"W4281755690","doi":"10.1200/jco.2022.40.16_suppl.tps3167","title":"Design and rationale of a phase 1 dose-escalation study of AMG 193, a methylthioadenosine (MTA)-cooperative PRMT5 inhibitor, in patients with advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Amgen","keywords":"Medicine; Protein arginine methyltransferase 5; Cancer research; CDKN2A; Cancer; Tolerability; Pharmacology; Methyltransferase; Internal medicine; Adverse effect; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002432276,0.0001898787,0.001070908,0.0001963294,0.00007117604,0.000005835549,0.0001696636,0.0002031816,0.00003503974],"category_scores_gemma":[0.0009664822,0.0001615249,0.0001184032,0.000354821,0.0001802816,0.00003143133,0.0001317554,0.0005503681,2.325759e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000128422,"about_ca_system_score_gemma":0.001124872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002018639,"about_ca_topic_score_gemma":0.00005358662,"domain_scores_codex":[0.9952059,0.001426219,0.002346799,0.0003357962,0.0005071836,0.0001781052],"domain_scores_gemma":[0.9957237,0.0004671766,0.002691659,0.0002036808,0.0007888986,0.0001248307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1391611,0.0493506,0.05496219,0.00009765124,0.001743283,0.00008957374,0.003616982,0.316885,0.3002264,0.0000291795,0.001417939,0.1324201],"study_design_scores_gemma":[0.1505529,0.3608032,0.3401116,0.0001881404,0.0007999107,0.00007940446,0.002196927,0.003915512,0.1375439,0.0002112257,0.002862026,0.0007352917],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995785,0.0009443604,0.001593746,0.0003110838,0.0002780253,0.001056218,0.00001636189,0.000002499032,0.00001268577],"genre_scores_gemma":[0.9961525,0.0001236399,0.003354002,0.00009954817,0.0001425248,0.00003986659,0.00003961199,0.00002342614,0.00002492118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3129695,"threshold_uncertainty_score":0.6586797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03601285776840743,"score_gpt":0.3841774413935174,"score_spread":0.34816458362511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}