{"id":"W4281762015","doi":"10.1101/2022.06.01.494373","title":"Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping combined with genome sequence analysis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Ontario Genomics; McGill University; Montreal Heart Institute; McGill Genome Centre","funders":"","keywords":"Epitope; Biology; Virology; Immune system; Antibody; Computational biology; Antigen; Epitope mapping; Coronavirus; Genome; Pandemic; Immunology; Genetics; Gene; Coronavirus disease 2019 (COVID-19); Medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004171851,0.0004155859,0.0005605512,0.0004472865,0.0002635741,0.0005802114,0.0003994011,0.0003904293,0.0007194682],"category_scores_gemma":[0.0008140327,0.0002289544,0.0006782874,0.0004051624,0.0002339374,0.0004072457,0.0003469817,0.0004816789,0.0001197695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220866,"about_ca_system_score_gemma":0.0004364513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003087434,"about_ca_topic_score_gemma":0.003905369,"domain_scores_codex":[0.9998852,0.0000355553,0.000005059307,0.00003406775,0.00001822364,0.00002186011],"domain_scores_gemma":[0.9998071,0.0001013489,0.00002807874,0.00001686555,0.0000240398,0.00002257284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0007849526,0.0004617445,0.1417259,0.0002268103,0.0004470733,0.0005534858,0.0001783735,0.7318647,0.09417334,0.001851333,0.001722526,0.02600985],"study_design_scores_gemma":[0.00002604256,0.00006693129,0.01454029,0.000002875956,0.00002853848,0.00005072962,0.00005420866,0.9807904,0.003382899,0.0008211777,0.0002278182,0.000008118952],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909018,0.00009715163,0.007981718,0.00009622226,0.000007013861,0.00001439465,0.0003515354,0.0001919816,0.0003582289],"genre_scores_gemma":[0.9899538,0.00005000619,0.008866256,0.00006643584,0.000006761576,0.00001526514,0.0008999853,0.00002292456,0.0001186053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003087434,"threshold_uncertainty_score":0.006138921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03623474373659039,"score_gpt":0.2916911865467174,"score_spread":0.255456442810127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}