{"id":"W4281766574","doi":"10.1002/chem.202200906","title":"A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"NanoMedicines Innovation Network","keywords":"Coronavirus disease 2019 (COVID-19); Key (lock); Yield (engineering); Component (thermodynamics); Sequence (biology); Virology; Computer science; Computational biology; Chemistry; Medicine; Biology; Physics; Internal medicine; Biochemistry; Computer security","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305507,0.0004830316,0.0002756802,0.0003023868,0.0003364533,0.0005222557,0.0003579739,0.0006397311,0.004046957],"category_scores_gemma":[0.0002365757,0.0002154476,0.0004763458,0.0001886539,0.0003304906,0.0004204299,0.0005867176,0.00134758,0.003740765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003890911,"about_ca_system_score_gemma":0.0006156177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004091388,"about_ca_topic_score_gemma":0.0005348062,"domain_scores_codex":[0.9998323,0.00003485252,0.00001602148,0.00003181357,0.00005177729,0.00003332521],"domain_scores_gemma":[0.9999025,0.0000139137,0.00002161271,0.00001622187,0.00001742972,0.00002837515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001398925,0.00006568219,0.00008396412,0.000157943,0.00001254964,0.0001994696,0.00006419996,0.000268468,0.9807886,0.002908573,0.0005042474,0.0148064],"study_design_scores_gemma":[0.00004864655,0.0006631158,0.0002584036,0.00002138207,0.00003162583,0.0007473796,0.00003022504,0.0004374567,0.9520757,0.0005345626,0.04513223,0.0000191148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6072221,0.008998074,0.3286235,0.003845106,0.001773035,0.001403389,0.002899521,0.002138264,0.04309697],"genre_scores_gemma":[0.770694,0.006157507,0.1718359,0.0009217175,0.0002010904,0.0005264276,0.003208244,0.0005672801,0.04588782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004046957,"threshold_uncertainty_score":0.01353836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172176141884704,"score_gpt":0.2314418139165979,"score_spread":0.2197200524977509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}