{"id":"W4281766717","doi":"10.26434/chemrxiv-2022-j87g9","title":"Total Synthesis of Matrine Alkaloids","year":2022,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; Université de Sherbrooke","keywords":"Matrine; Natural product; Total synthesis; Chemistry; Intramolecular force; Diastereomer; Stereochemistry; Covalent bond; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409733,0.0005121395,0.0004262399,0.0004227525,0.0002862697,0.0003701224,0.0003850515,0.0002321395,0.004531754],"category_scores_gemma":[0.0001232415,0.0001961127,0.0003504872,0.0003391112,0.0001505776,0.0004811282,0.0005003676,0.0006538838,0.002609374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067836,"about_ca_system_score_gemma":0.0003397914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001783624,"about_ca_topic_score_gemma":0.0004304399,"domain_scores_codex":[0.9998778,0.00001445207,0.00001328711,0.00002941129,0.00004032157,0.00002475454],"domain_scores_gemma":[0.9999318,0.000006003499,0.00001141186,0.00001810693,0.00001380406,0.00001878644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542319,0.000075079,0.0001902638,0.000834266,0.00006644295,0.0005405606,0.00018611,0.0007303858,0.9473677,0.005174139,0.0008872399,0.04379348],"study_design_scores_gemma":[0.00003656816,0.0006526036,0.0012208,0.0000762372,0.0001021979,0.001218126,0.0000432811,0.0007740468,0.9146529,0.001071743,0.08011986,0.00003180526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7074324,0.0238781,0.1229843,0.0005356101,0.0006782595,0.0009555701,0.0108192,0.002438087,0.1302786],"genre_scores_gemma":[0.8947998,0.01499628,0.05680089,0.0002193785,0.00009104853,0.0003529268,0.00451726,0.000362919,0.0278594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004531754,"threshold_uncertainty_score":0.0151602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065578277142124,"score_gpt":0.2548693604411354,"score_spread":0.2442135776697142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}