{"id":"W4281767317","doi":"10.21203/rs.3.rs-1696103/v1","title":"Deficiency of IKKβ in neurons ameliorates Alzheimer’s disease pathology in APP- and tau-transgenic mice","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität zu Köln; China Scholarship Council; University of Toronto; Alzheimer Forschung Initiative; National Natural Science Foundation of China; Youth Science Foundation of Jiangxi Province; Universität des Saarlandes","keywords":"Genetically modified mouse; Morris water navigation task; Tau protein; Neuroinflammation; Transgene; Cell biology; Phosphorylation; Kinase; Biology; IκB kinase; Alzheimer's disease; Chemistry; Neuroscience; Molecular biology; Internal medicine; NF-κB; Hippocampus; Signal transduction; Immunology; Medicine; Biochemistry; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000242307,0.001491968,0.0006758042,0.001046962,0.0003038206,0.0005192118,0.0005014457,0.0006997822,0.00224217],"category_scores_gemma":[0.0001590132,0.0004556353,0.0005370798,0.0002818902,0.0005318974,0.0005150521,0.0003123542,0.001316867,0.0009400366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667386,"about_ca_system_score_gemma":0.0003664912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007001174,"about_ca_topic_score_gemma":0.0009588845,"domain_scores_codex":[0.9997025,0.00002544627,0.00006158893,0.00007191465,0.00005016312,0.00008829791],"domain_scores_gemma":[0.9995821,0.00002275335,0.0001411928,0.00004208796,0.00003933811,0.0001725172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006175179,0.0002351846,0.0001921208,0.00008400839,0.00001896943,0.00008664378,0.00003238533,0.00006617828,0.9972373,0.00008736265,0.00008131066,0.001261027],"study_design_scores_gemma":[0.0003589405,0.002483109,0.008814538,0.00008382531,0.000170544,0.000583159,0.0001667552,0.001332442,0.9824224,0.0003899941,0.003167032,0.00002727177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908836,0.002058048,0.003057164,0.000227997,0.0001373338,0.00008043419,0.001332175,0.0006043506,0.00161891],"genre_scores_gemma":[0.9875064,0.001836204,0.003374926,0.0001556332,0.00004739408,0.0001793081,0.001200602,0.0001622894,0.005537208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224217,"threshold_uncertainty_score":0.007500827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08689850114481278,"score_gpt":0.4156357747109056,"score_spread":0.3287372735660928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}