{"id":"W4281770506","doi":"10.1016/j.celrep.2022.110888","title":"Caulobacter lipid A is conditionally dispensable in the absence of fur and in the presence of anionic sphingolipids","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Lawrence Berkeley National Laboratory; National Institute of General Medical Sciences; European Regional Development Fund; National Institute of Allergy and Infectious Diseases; Fundacja na rzecz Nauki Polskiej; European Commission; Laboratory Directed Research and Development; U.S. Department of Energy; National Institutes of Health; National Science Foundation","keywords":"Sphingolipid; Lipid A; Caulobacter crescentus; Ceramide; Lipid II; Biochemistry; Biology; Cell biology; Lipidome; Response regulator; Lipopolysaccharide; Bacterial outer membrane; Chemistry; Lipid metabolism; Biosynthesis; Gene; Escherichia coli; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810702,0.0006636072,0.0003215411,0.0005414023,0.0003474301,0.0006541849,0.0006000704,0.0004897089,0.001205239],"category_scores_gemma":[0.0003328415,0.0003250687,0.000232483,0.000345572,0.000662394,0.0002940844,0.000779969,0.0007998332,0.0006547624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006779601,"about_ca_system_score_gemma":0.0007713075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004490433,"about_ca_topic_score_gemma":0.003567833,"domain_scores_codex":[0.999557,0.00004889692,0.00004903079,0.00009125211,0.0001675144,0.00008632773],"domain_scores_gemma":[0.9990115,0.0001812023,0.0002754135,0.0001802657,0.00008858561,0.0002629269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007034071,0.00002220038,0.0001274222,0.00001172384,0.000002681096,0.00007065494,0.000009994955,0.00004169139,0.9992218,0.0000957497,0.00002177445,0.000303932],"study_design_scores_gemma":[0.0000347285,0.0001098015,0.005558195,0.00001316349,0.00001325456,0.000464356,0.00007337837,0.001456634,0.9902462,0.0001308879,0.001882173,0.00001723207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952995,0.0003717128,0.001954682,0.0001478139,0.00002943323,0.00002273038,0.0006958511,0.0002166811,0.001261575],"genre_scores_gemma":[0.9948326,0.0001960566,0.00163049,0.00005723672,0.000009005248,0.00002682733,0.0007933383,0.0001204126,0.002333998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004490433,"threshold_uncertainty_score":0.008928597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007317111912895464,"score_gpt":0.2196036504750546,"score_spread":0.2122865385621592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}