{"id":"W4281770506","doi":"10.1016/j.celrep.2022.110888","title":"Caulobacter lipid A is conditionally dispensable in the absence of fur and in the presence of anionic sphingolipids","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Lawrence Berkeley National Laboratory; National Institute of General Medical Sciences; European Regional Development Fund; National Institute of Allergy and Infectious Diseases; Fundacja na rzecz Nauki Polskiej; European Commission; Laboratory Directed Research and Development; U.S. Department of Energy; National Institutes of Health; National Science Foundation","keywords":"Sphingolipid; Lipid A; Caulobacter crescentus; Ceramide; Lipid II; Biochemistry; Biology; Cell biology; Lipidome; Response regulator; Lipopolysaccharide; Bacterial outer membrane; Chemistry; Lipid metabolism; Biosynthesis; Gene; Escherichia coli; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004266239,0.00006422924,0.00009614679,0.00002763028,0.00003465855,0.000006600444,0.0001867966,0.00006201098,0.00003973499],"category_scores_gemma":[0.00003141238,0.00004376123,0.00002992689,0.0001204858,0.0001165333,0.000001849185,0.0001606372,0.0001046731,1.331386e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004521945,"about_ca_system_score_gemma":0.00005691786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008806711,"about_ca_topic_score_gemma":0.00008529774,"domain_scores_codex":[0.9992537,0.00007192598,0.0002488705,0.0001904995,0.0001235471,0.0001114387],"domain_scores_gemma":[0.9994485,0.00001953921,0.0001577247,0.000341193,0.00002352232,0.000009555095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002652541,0.0001083172,0.01595563,0.00002623893,0.000004720392,0.0000307466,0.0003535815,0.00003280446,0.9826264,0.00006709685,0.000664223,0.0001037037],"study_design_scores_gemma":[0.0004775174,0.0006203938,0.1835975,0.00002185423,0.00001392266,0.0006586915,0.001507121,0.00004113714,0.7237878,0.001214676,0.08783589,0.0002234064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983022,0.0003094139,0.000003039775,0.0003764478,0.00008492873,0.0001676262,0.00001748908,9.518313e-7,0.0007379035],"genre_scores_gemma":[0.9993982,0.0001584508,0.00003663355,0.0002117356,0.000031274,0.00002362019,0.00003041508,0.000004006287,0.0001056683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2588386,"threshold_uncertainty_score":0.1784531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007317111912895464,"score_gpt":0.2196036504750546,"score_spread":0.2122865385621592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}