{"id":"W4281771908","doi":"10.26685/urncst.303","title":"Limiting Immunogenicity of Diabetic Retinopathy Patient-Derived Induced Pluripotent Stem Cells by Knocking out Human Leukocyte Antigen and Overexpressing Cluster of Differentiation 47","year":2022,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Induced pluripotent stem cell; Human leukocyte antigen; Biology; Immunogenicity; Immunology; Immune system; Endothelial stem cell; Antigen; Stem cell; Cell therapy; Cell biology; Cancer research; Embryonic stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003240167,0.0002604582,0.0002162379,0.0001895375,0.00009265824,0.0003497479,0.0001802042,0.0002901617,0.001513234],"category_scores_gemma":[0.0002202144,0.00009295383,0.000286235,0.0001355602,0.000142832,0.0001246286,0.0002710001,0.0003563605,0.0004416538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618103,"about_ca_system_score_gemma":0.0001818199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001617631,"about_ca_topic_score_gemma":0.0001744981,"domain_scores_codex":[0.9997351,0.00003026015,0.00003564902,0.00004460001,0.000114468,0.00004001906],"domain_scores_gemma":[0.9998291,0.00002830537,0.00005823341,0.00003155416,0.00003299829,0.00001976943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007128036,0.00003545216,0.000648834,0.0001461514,0.00001525517,0.000179517,0.00003074807,0.000428107,0.9911299,0.000393917,0.0002750107,0.006645917],"study_design_scores_gemma":[0.00001818735,0.0003660818,0.002304091,0.00002453365,0.00005680553,0.0006887561,0.00002384814,0.001179887,0.9871073,0.00009693403,0.008125556,0.00000784752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723939,0.002547822,0.01755921,0.0002329819,0.0001307187,0.0001510304,0.001208936,0.0004138954,0.005361479],"genre_scores_gemma":[0.9876131,0.001623249,0.005893989,0.0001409945,0.00001308336,0.0001025919,0.001600172,0.0000524845,0.002960379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513234,"threshold_uncertainty_score":0.005062282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616866523060929,"score_gpt":0.3347794457650874,"score_spread":0.2886107805344781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}