{"id":"W4281774845","doi":"10.15386/mpr-2305","title":"Clinically significant drug interactions between antiretroviral and co-prescribed drugs in HIV infected patients: retrospective cohort study","year":2022,"lang":"en","type":"article","venue":"Medicine and Pharmacy Reports","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"","keywords":"Medicine; Retrospective cohort study; Dolutegravir; Odds ratio; Internal medicine; Ritonavir; Integrase inhibitor; Clinical significance; Cohort study; Drug; Cohort; Dyslipidemia; Logistic regression; Reverse-transcriptase inhibitor; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy; Pharmacology; Virology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000735034,0.0002570559,0.0004681103,0.001080437,0.0006597583,0.0006758058,0.0004004616,0.0004001899,0.001609131],"category_scores_gemma":[0.001507056,0.0004443472,0.0004786311,0.001587873,0.000275356,0.0005334421,0.0004932758,0.000569667,0.0002202155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082317,"about_ca_system_score_gemma":0.0004134036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004180501,"about_ca_topic_score_gemma":0.005260251,"domain_scores_codex":[0.9993004,0.0001370926,0.0001213358,0.0001914614,0.0001571393,0.00009251874],"domain_scores_gemma":[0.9985714,0.0002178889,0.0007471706,0.0001457498,0.0001218903,0.0001958397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003221413,0.0000200235,0.9994708,0.000009854501,0.00002624733,0.00008853839,0.00003962523,0.000007229736,0.00004564077,0.00000471969,0.00002651454,0.0002284867],"study_design_scores_gemma":[0.00000680328,0.0001435839,0.9984011,0.00001414317,0.00004185997,0.0007869735,0.000282298,0.00009573467,0.00003846734,0.00001097264,0.0001739892,0.000004028097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988494,0.0003110144,0.00006518432,0.000018894,0.000004644245,0.00003190219,0.0004858985,0.000001777075,0.0002312204],"genre_scores_gemma":[0.9991764,0.0002069923,0.00008635398,0.0000322512,0.000009250582,0.00002813679,0.0003803971,0.000001118146,0.00007900593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004180501,"threshold_uncertainty_score":0.008312345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117192529397648,"score_gpt":0.3878532790770101,"score_spread":0.3566813537830336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}